MP-SeNPs; A Promising Cytokines Suppressor in Benzo[a]pyrene-Induced Mammal Tissue Injury in Rats.
Pak J Biol Sci
; 24(8): 895-904, 2021 Jan.
Article
em En
| MEDLINE
| ID: mdl-34486357
ABSTRACT
<b>Background and Objective:
</b> <i>Moringa peregrina</i> (family Moringaceae) is a common flowering plant found in the Arabian Peninsula, Horn of Africa and Southern Sinai, Egypt. The purpose of this study was to investigate the protective activity of MP-SeNPs against BaP-induced mammal tissue injury in rats. <b>Materials andMethods:
</b> MP-SeNPs were prepared and characterized in terms of particle size and zeta potential. Furthermore, the IC<sub>50</sub> of MP-SeNPs against the Mcf7 breast carcinoma cell line and LD<sub>50</sub> was evaluated. Adult albino rats weighing approximately 187±10 g was used to assess the lung protective activity of MP-SeNPs (28.7 and 71.75 mg kg<sup>1</sup> b.wt.) against BaP-induced mammal tissue injury in rats. <b>Results:
</b> The mean particle size of MP-SeNPs was 134.69±8.24 nm with negative zeta potential of +26.04 with the observed shapes of nano particle was spherical. Also, IC<sub>50</sub> of MP-SeNPs against Mcf7 breast carcinoma cell line = 89.57 µg mL<sup>1</sup> and LD<sub>50</sub> equals and 1435 mg kg<sup>1</sup> b.wt., respectively. The daily oral administration of MP-SeNPs at concentrations of 28.7 and 71.75 mg kg<sup>1</sup> b.wt. for 30 days to rats treated with BaP (20 mg kg<sup>1</sup> b.wt.) resulted in a significant improvement of IL-2, IL-6 and IL-10. Oral administration of MP-SeNPs, on the other hand, increased the levels of SOD, GPx, TNF-α, iNOs and GSH as well as decreased the level of MDA in mammal tissue of BaP-treated rats. Furthermore, MP-SeNPs almost normalized these effects in mammal tissue histoarchitecture and MRI examination. <b>Conclusion:
</b> The biochemical, histological and MRI findings incurrent study demonstrated that MP-SeNPs have protective activity against BaP-induced mammal tissue injury in rats.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Benzo(a)pireno
/
Estresse Oxidativo
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Antioxidantes
Limite:
Animals
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Female
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Humans
Idioma:
En
Revista:
Pak J Biol Sci
Ano de publicação:
2021
Tipo de documento:
Article