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Anti-schistosomal activities of quinoxaline-containing compounds: From hit identification to lead optimisation.
Padalino, Gilda; El-Sakkary, Nelly; Liu, Lawrence J; Liu, Chenxi; Harte, Danielle S G; Barnes, Rachel E; Sayers, Edward; Forde-Thomas, Josephine; Whiteland, Helen; Bassetto, Marcella; Ferla, Salvatore; Johnson, George; Jones, Arwyn T; Caffrey, Conor R; Chalmers, Iain; Brancale, Andrea; Hoffmann, Karl F.
Afiliação
  • Padalino G; Institute of Biological, Environmental and Rural Sciences (IBERS), Aberystwyth University, Aberystwyth, SY23 3DA, United Kingdom.
  • El-Sakkary N; Center for Discovery and Innovation in Parasitic Diseases (CDIPD), Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
  • Liu LJ; Center for Discovery and Innovation in Parasitic Diseases (CDIPD), Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
  • Liu C; Center for Discovery and Innovation in Parasitic Diseases (CDIPD), Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
  • Harte DSG; Swansea University Medical School, Swansea University, Swansea, SA2 8PP, United Kingdom.
  • Barnes RE; Swansea University Medical School, Swansea University, Swansea, SA2 8PP, United Kingdom.
  • Sayers E; School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff, CF10 3NB, United Kingdom.
  • Forde-Thomas J; Institute of Biological, Environmental and Rural Sciences (IBERS), Aberystwyth University, Aberystwyth, SY23 3DA, United Kingdom.
  • Whiteland H; Institute of Biological, Environmental and Rural Sciences (IBERS), Aberystwyth University, Aberystwyth, SY23 3DA, United Kingdom.
  • Bassetto M; Department of Chemistry, College of Science and Engineering, Swansea University, Swansea, SA2 8PP, United Kingdom.
  • Ferla S; Swansea University Medical School, Swansea University, Swansea, SA2 8PP, United Kingdom.
  • Johnson G; Swansea University Medical School, Swansea University, Swansea, SA2 8PP, United Kingdom.
  • Jones AT; School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff, CF10 3NB, United Kingdom.
  • Caffrey CR; Center for Discovery and Innovation in Parasitic Diseases (CDIPD), Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
  • Chalmers I; Institute of Biological, Environmental and Rural Sciences (IBERS), Aberystwyth University, Aberystwyth, SY23 3DA, United Kingdom.
  • Brancale A; School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff, CF10 3NB, United Kingdom.
  • Hoffmann KF; Institute of Biological, Environmental and Rural Sciences (IBERS), Aberystwyth University, Aberystwyth, SY23 3DA, United Kingdom. Electronic address: krh@aber.ac.uk.
Eur J Med Chem ; 226: 113823, 2021 Dec 15.
Article em En | MEDLINE | ID: mdl-34536671
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Contexto em Saúde: 3_ND Problema de saúde: 3_helminthiasis / 3_neglected_diseases / 3_schistosomiasis / 3_zoonosis Assunto principal: Quinoxalinas / Schistosoma haematobium / Schistosoma japonicum / Schistosoma mansoni / Esquistossomose mansoni Tipo de estudo: Diagnostic_studies Limite: Animals / Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Contexto em Saúde: 3_ND Problema de saúde: 3_helminthiasis / 3_neglected_diseases / 3_schistosomiasis / 3_zoonosis Assunto principal: Quinoxalinas / Schistosoma haematobium / Schistosoma japonicum / Schistosoma mansoni / Esquistossomose mansoni Tipo de estudo: Diagnostic_studies Limite: Animals / Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Reino Unido