Vaccination induces rapid protection against bacterial pneumonia via training alveolar macrophage in mice.
Elife
; 102021 09 20.
Article
em En
| MEDLINE
| ID: mdl-34544549
ABSTRACT
Vaccination strategies for rapid protection against multidrug-resistant bacterial infection are very important, especially for hospitalized patients who have high risk of exposure to these bacteria. However, few such vaccination strategies exist due to a shortage of knowledge supporting their rapid effect. Here, we demonstrated that a single intranasal immunization of inactivated whole cell of Acinetobacter baumannii elicits rapid protection against broad A. baumannii-infected pneumonia via training of innate immune response in Rag1-/- mice. Immunization-trained alveolar macrophages (AMs) showed enhanced TNF-α production upon restimulation. Adoptive transfer of immunization-trained AMs into naive mice mediated rapid protection against infection. Elevated TLR4 expression on vaccination-trained AMs contributed to rapid protection. Moreover, immunization-induced rapid protection was also seen in Pseudomonas aeruginosa and Klebsiella pneumoniae pneumonia models, but not in Staphylococcus aureus and Streptococcus pneumoniae model. Our data reveal that a single intranasal immunization induces rapid and efficient protection against certain Gram-negative bacterial pneumonia via training AMs response, which highlights the importance and the possibility of harnessing trained immunity of AMs to design rapid-effecting vaccine.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Contexto em Saúde:
2_ODS3
/
3_ND
/
4_TD
Problema de saúde:
2_enfermedades_transmissibles
/
3_neglected_diseases
/
3_zoonosis
/
4_pneumonia
Assunto principal:
Pseudomonas aeruginosa
/
Infecções por Pseudomonas
/
Infecções por Acinetobacter
/
Infecções por Klebsiella
/
Vacinas Bacterianas
/
Macrófagos Alveolares
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Pneumonia Bacteriana
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Acinetobacter baumannii
/
Klebsiella pneumoniae
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Elife
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
China