The enigma of phosphoinositides and their derivatives: Their role in regulation of subcellular compartment morphology.
Biochim Biophys Acta Biomembr
; 1864(1): 183780, 2022 02 01.
Article
em En
| MEDLINE
| ID: mdl-34547252
ABSTRACT
The general segregation of a molecular class, lipids, from the pathways of cellular communication, via endo-membranes, has resulted in the over-simplification and misconceptions in deciphering cell signalling mechanisms. Mechanisms in signal transduction and protein activation require targeting of proteins to membranous compartments with a specific localised morphology and dynamics that are dependent on their lipid composition. Many posttranslational events define cellular behaviours and without the active role of membranous compartments these events lead to various dysregulations of the signalling pathways. We summarise the key findings, using tools such as the rapalogue dimerisation, in the structural roles and signalling of the inter-related phosphoinositide lipids and their derivative, diacylglycerol, in the regulation of nuclear envelope biogenesis and other subcellular compartments such as the nucleoplasmic reticulum.
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Texto completo:
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fosfatidilinositóis
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Transdução de Sinais
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Comunicação Celular
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Lipídeos de Membrana
Idioma:
En
Revista:
Biochim Biophys Acta Biomembr
Ano de publicação:
2022
Tipo de documento:
Article