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Glioblastoma Clinical Trials: Current Landscape and Opportunities for Improvement.
Bagley, Stephen J; Kothari, Shawn; Rahman, Rifaquat; Lee, Eudocia Q; Dunn, Gavin P; Galanis, Evanthia; Chang, Susan M; Nabors, Louis Burt; Ahluwalia, Manmeet S; Stupp, Roger; Mehta, Minesh P; Reardon, David A; Grossman, Stuart A; Sulman, Erik P; Sampson, John H; Khagi, Simon; Weller, Michael; Cloughesy, Timothy F; Wen, Patrick Y; Khasraw, Mustafa.
Afiliação
  • Bagley SJ; Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
  • Kothari S; Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
  • Rahman R; Department of Radiation Oncology, Dana-Farber/Brigham and Women's Cancer Center, Harvard Medical School, Boston, Massachusetts.
  • Lee EQ; Center for Neuro-Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
  • Dunn GP; Department of Neurological Surgery, Washington University School of Medicine, St Louis, Missouri.
  • Galanis E; Division of Medical Oncology, Mayo Clinic, Rochester, Minnesota.
  • Chang SM; Department of Neurological Surgery, University of California San Francisco, San Francisco, California.
  • Nabors LB; Division of Neuro-oncology, Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama.
  • Ahluwalia MS; Department of Medical Oncology, Miami Cancer Institute, Baptist Health South Florida, Miami, Florida.
  • Stupp R; Department of Medicine, Northwestern University, Chicago, Illinois.
  • Mehta MP; Department of Radiation Oncology, Miami Cancer Institute, Baptist Health South Florida, Miami, Florida.
  • Reardon DA; Center for Neuro-Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
  • Grossman SA; Department of Oncology, Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland.
  • Sulman EP; Department of Radiation Oncology, NYU Grossman School of Medicine, New York, New York.
  • Sampson JH; Preston Robert Tisch Brain Tumor Center, Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina.
  • Khagi S; Division of Hematology/Oncology, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina.
  • Weller M; Department of Neurology and Brain Tumor Center, University Hospital and University of Zurich, Zurich, Switzerland.
  • Cloughesy TF; Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.
  • Wen PY; Center for Neuro-Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
  • Khasraw M; Preston Robert Tisch Brain Tumor Center, Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina.
Clin Cancer Res ; 28(4): 594-602, 2022 02 15.
Article em En | MEDLINE | ID: mdl-34561269
ABSTRACT
Therapeutic advances for glioblastoma have been minimal over the past 2 decades. In light of the multitude of recent phase III trials that have failed to meet their primary endpoints following promising preclinical and early-phase programs, a Society for Neuro-Oncology Think Tank was held in November 2020 to prioritize areas for improvement in the conduct of glioblastoma clinical trials. Here, we review the literature, identify challenges related to clinical trial eligibility criteria and trial design in glioblastoma, and provide recommendations from the Think Tank. In addition, we provide a data-driven context with which to frame this discussion by analyzing key study design features of adult glioblastoma clinical trials listed on ClinicalTrials.gov as "recruiting" or "not yet recruiting" as of February 2021.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Glioblastoma Tipo de estudo: Diagnostic_studies / Guideline / Prognostic_studies Limite: Adult / Humans Idioma: En Revista: Clin Cancer Res Assunto da revista: NEOPLASIAS Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Glioblastoma Tipo de estudo: Diagnostic_studies / Guideline / Prognostic_studies Limite: Adult / Humans Idioma: En Revista: Clin Cancer Res Assunto da revista: NEOPLASIAS Ano de publicação: 2022 Tipo de documento: Article