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The C-terminal peptide of CCL21 drastically augments CCL21 activity through the dendritic cell lymph node homing receptor CCR7 by interaction with the receptor N-terminus.
Jørgensen, Astrid Sissel; Brandum, Emma Probst; Mikkelsen, Jeppe Malthe; Orfin, Klaudia A; Boilesen, Ditte Rahbæk; Egerod, Kristoffer Lihme; Moussouras, Natasha A; Vilhardt, Frederik; Kalinski, Pawel; Basse, Per; Chen, Yen-Hsi; Yang, Zhang; Dwinell, Michael B; Volkman, Brian F; Veldkamp, Christopher T; Holst, Peter Johannes; Lahl, Katharina; Goth, Christoffer Knak; Rosenkilde, Mette Marie; Hjortø, Gertrud Malene.
Afiliação
  • Jørgensen AS; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, Room 18.5.32., 2200, Copenhagen, Denmark.
  • Brandum EP; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, Room 18.5.32., 2200, Copenhagen, Denmark.
  • Mikkelsen JM; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, Room 18.5.32., 2200, Copenhagen, Denmark.
  • Orfin KA; Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.
  • Boilesen DR; Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.
  • Egerod KL; Novo Nordisk Foundation, Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
  • Moussouras NA; Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI, USA.
  • Vilhardt F; Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.
  • Kalinski P; Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
  • Basse P; Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
  • Chen YH; Copenhagen Center for Glycomics, University of Copenhagen, Copenhagen, Denmark.
  • Yang Z; Copenhagen Center for Glycomics, University of Copenhagen, Copenhagen, Denmark.
  • Dwinell MB; Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI, USA.
  • Volkman BF; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI, USA.
  • Veldkamp CT; Department of Chemistry, University of Wisconsin-Whitewater, Whitewater, WI, USA.
  • Holst PJ; Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.
  • Lahl K; Immunology Section, Lund University, 221 84, Lund, Sweden.
  • Goth CK; Section for Experimental and Translational Immunology, Department of Health Technology, Technical University of Denmark (DTU), Lyngby, Denmark.
  • Rosenkilde MM; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, Room 18.5.32., 2200, Copenhagen, Denmark.
  • Hjortø GM; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, Room 18.5.32., 2200, Copenhagen, Denmark.
Cell Mol Life Sci ; 78(21-22): 6963-6978, 2021 Nov.
Article em En | MEDLINE | ID: mdl-34586443
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células Dendríticas / Transdução de Sinais / Receptores de Retorno de Linfócitos / Quimiocina CCL21 / Receptores CCR7 / Linfonodos Limite: Animals / Humans Idioma: En Revista: Cell Mol Life Sci Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Dinamarca
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células Dendríticas / Transdução de Sinais / Receptores de Retorno de Linfócitos / Quimiocina CCL21 / Receptores CCR7 / Linfonodos Limite: Animals / Humans Idioma: En Revista: Cell Mol Life Sci Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Dinamarca