Role of the posterior mucosal defense barrier in portal hypertensive gastropathy.
Biomed Pharmacother
; 144: 112258, 2021 Dec.
Article
em En
| MEDLINE
| ID: mdl-34614465
ABSTRACT
Portal hypertensive gastropathy (PHG) is a complication of cirrhotic or noncirrhotic portal hypertension. PHG is very important in the clinic because it can cause acute or even massive blood loss, and its treatment efficacy and prognosis are poor. Currently, the incidence of PHG in patients with cirrhosis is 20-80%, but its pathogenesis is complicated and poorly understood. Studies have shown that portal hypertension can cause changes in gastric mucosal microcirculation hemodynamics, leading to changes in gastric mucosal histology and function and thereby weakening the mucosal defense barrier. However, no specific drug treatment plans are currently available. This article reviews the current literature to further our understanding of the mechanism underlying PHG and the relationship between PHG and the posterior mucosal defense barrier and to explore new therapeutic targets.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Circulação Esplâncnica
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Gastropatias
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Células Endoteliais
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Mucosa Gástrica
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Hemodinâmica
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Hipertensão Portal
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Microcirculação
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Biomed Pharmacother
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
China