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Novel small molecule inhibition of IKK/NF-κB activation reduces markers of senescence and improves healthspan in mouse models of aging.
Zhang, Lei; Zhao, Jing; Mu, Xiaodong; McGowan, Sara J; Angelini, Luise; O'Kelly, Ryan D; Yousefzadeh, Matthew J; Sakamoto, Ayumi; Aversa, Zaira; LeBrasseur, Nathan K; Suh, Yousin; Huard, Johnny; Kamenecka, Theodore M; Niedernhofer, Laura J; Robbins, Paul D.
Afiliação
  • Zhang L; Department of Biochemistry, Molecular Biology and Biophysics, Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, Minnesota, USA.
  • Zhao J; Department of Molecular Medicine, Scripps Research, Jupiter, Florida, USA.
  • Mu X; Center for Regenerative Sports Medicine, Steadman Philippon Research Institute, Vail, Colorado, USA.
  • McGowan SJ; Shandong First Medical University (Shandong Academy of Medical Sciences), Jinan, China.
  • Angelini L; Department of Biochemistry, Molecular Biology and Biophysics, Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, Minnesota, USA.
  • O'Kelly RD; Department of Biochemistry, Molecular Biology and Biophysics, Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, Minnesota, USA.
  • Yousefzadeh MJ; Department of Biochemistry, Molecular Biology and Biophysics, Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, Minnesota, USA.
  • Sakamoto A; Department of Biochemistry, Molecular Biology and Biophysics, Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, Minnesota, USA.
  • Aversa Z; Department of Physical Medicine and Rehabilitation and Robert and Arlene Kogod Center on Aging, Rochester, Minnesota, USA.
  • LeBrasseur NK; Department of Physical Medicine and Rehabilitation and Robert and Arlene Kogod Center on Aging, Rochester, Minnesota, USA.
  • Suh Y; Department of Physical Medicine and Rehabilitation and Robert and Arlene Kogod Center on Aging, Rochester, Minnesota, USA.
  • Huard J; Department of Genetics and Development, Columbia University, New York, New York, USA.
  • Kamenecka TM; Center for Regenerative Sports Medicine, Steadman Philippon Research Institute, Vail, Colorado, USA.
  • Niedernhofer LJ; Department of Molecular Medicine, Scripps Research, Jupiter, Florida, USA.
  • Robbins PD; Department of Biochemistry, Molecular Biology and Biophysics, Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, Minnesota, USA.
Aging Cell ; 20(12): e13486, 2021 12.
Article em En | MEDLINE | ID: mdl-34734460
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regulação da Expressão Gênica / NF-kappa B / Senescência Celular / Quinase I-kappa B Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Aging Cell Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regulação da Expressão Gênica / NF-kappa B / Senescência Celular / Quinase I-kappa B Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Aging Cell Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos