Pulmonary injury as a predictor of cerebral hypoxia in traumatic brain injury: from physiology to physiopathology.
J Neurosurg Sci
; 66(3): 251-257, 2022 Jun.
Article
em En
| MEDLINE
| ID: mdl-34763389
ABSTRACT
Traumatic brain injury is caused by mechanical forces impacting the skull and its internal structures and constitutes one of the main causes of morbidity and mortality in the world. Clinically, severe traumatic brain injury is associated with the development of acute lung injury and so far, few studies have evaluated the cellular, molecular and immunological mechanisms involved in this pathophysiological process. Knowing and investigating these mechanisms allows us to correlate pulmonary injury as a predictor of cerebral hypoxia in traumatic brain injury and to use this finding in decision making during clinical practice. This review aims to provide evidence on the importance of the pathophysiology of traumatic brain injury-acute lung injury, and thus confirm its role as a predictor of cerebral hypoxia, helping to establish an appropriate therapeutic strategy to improve functional outcomes and reduce mortality.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Contexto em Saúde:
6_ODS3_enfermedades_notrasmisibles
Problema de saúde:
6_other_respiratory_diseases
Assunto principal:
Hipóxia Encefálica
/
Lesão Pulmonar Aguda
/
Lesões Encefálicas Traumáticas
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
J Neurosurg Sci
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Colômbia