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Treatment of perioperative swelling by rest, ice, compression, and elevation (RICE) without and with additional application of negative pressure (RICE+) in patients with a unilateral ankle fracture: study protocol for a monocentric, evaluator-blinded randomized controlled pilot trial.
Fischer, Dagmar-C; Sckell, Axel; Garkisch, Angelina; Dresing, Klaus; Eisenhauer, Anton; Valentini, Luzia; Mittlmeier, Thomas.
Afiliação
  • Fischer DC; Department of Pediatrics, Rostock University Medical Center, Ernst-Heydemann-Str. 8, 18057, Rostock, Germany. dagmar-christiane.fischer@med.uni-rostock.de.
  • Sckell A; Department of Traumatology, Hand and Reconstructive Surgery, Rostock University Medical Center, Rostock, Germany.
  • Garkisch A; Department of Traumatology, Hand and Reconstructive Surgery, Rostock University Medical Center, Rostock, Germany.
  • Dresing K; Department of Trauma Surgery, Orthopaedics and Plastic Surgery, University Medicine Göttingen, Georg-August-University, Göttingen, Germany.
  • Eisenhauer A; GEOMAR Helmholtz Center for Ocean Research Kiel, Kiel, Germany.
  • Valentini L; Department of Agriculture and Food Sciences, Neubrandenburg Institute for Evidence-Based Dietetics (NIED), University of Applied Sciences Neubrandenburg, Neubrandenburg, Germany.
  • Mittlmeier T; Department of Traumatology, Hand and Reconstructive Surgery, Rostock University Medical Center, Rostock, Germany.
Pilot Feasibility Stud ; 7(1): 203, 2021 Nov 12.
Article em En | MEDLINE | ID: mdl-34772457
ABSTRACT

BACKGROUND:

Edema is commonly seen after surgical fixation of ankle fractures. Rest, ice, compression, and elevation (RICE) is an established combination to prevent swelling but hardly able to stimulate lymphatic resorption. Recently, an epicutaneously applied negative pressure suction apparatus (LymphaTouch®) has been introduced to stimulate lymphatic flow. While postoperative recovery, soft tissue, and osseous healing as well as functional outcome are probably linked to the amount of postoperative swelling, estimates on this relative to prevention (RICE) or prevention + stimulated resorption (RICE+) of fluid are scarce. METHODS AND

ANALYSIS:

This is a single-center, evaluator-blinded randomized pilot trial to investigate postoperative swelling in adults requiring surgical fixation of a closed unilateral ankle fracture. A total of 50 patients will be recruited and randomly assigned to RICE or RICE+ prior to surgery. All patients will undergo evaluator-blinded measurements of the ankle volume the day before surgery and subsequently from the evening of the 2nd postoperative day every 24 h until discharge. RICE will be initiated right after surgery and continued until discharge from the hospital in all patients. Additional application of negative pressure therapy (RICE+) will be initiated on the morning of the 2nd postoperative day and repeated every 24 h until the time of discharge from the hospital. Outcome measures are (i) the relative amount and the time course of the postoperative swelling, (ii) the demand for analgesic therapy (type and amount) together with the perception of pain, (iii) the rate of complications, and (iv) mobility of the ankle joint and the recovery of walking abilities during a 12-weeks follow-up period. Serum and urine samples taken prior to sugery and during postoperative recovery will allow to evaluate the ratio of naturally occurring stable calcium isotopes (δ44/42Ca) as a marker of skeletal calcium accrual. ETHICS AND DISSEMINATION The protocol was approved by the institutional Ethics Committee (Rostock University Medical Center, Rostock, Germany) in accordance with the Declaration of Helsinki (approval number A 2020-0092). The results of this study will be actively disseminated through scientific publications and conference presentations. TRIAL REGISTRATION DRKS, DRKS00023739 . Registered on 14 December 2020.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Clinical_trials / Guideline Aspecto: Ethics Idioma: En Revista: Pilot Feasibility Stud Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Alemanha

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Clinical_trials / Guideline Aspecto: Ethics Idioma: En Revista: Pilot Feasibility Stud Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Alemanha
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