The Expression of RAAS Key Receptors, <i>Agtr2</i> and <i>Bdkrb1</i>, Is Downregulated at an Early Stage in a Rat Model of Wolfram Syndrome.

Punapart, Marite; Seppa, Kadri; Jagomäe, Toomas; Liiv, Mailis; Reimets, Riin; Kirillov, Silvia; Kaasik, Allen; Moons, Lieve; De Groef, Lies; Terasmaa, Anton; Vasar, Eero; Plaas, Mario

The Expression of RAAS Key Receptors, Agtr2 and Bdkrb1, Is Downregulated at an Early Stage in a Rat Model of Wolfram Syndrome.

Punapart, Marite; Seppa, Kadri; Jagomäe, Toomas; Liiv, Mailis; Reimets, Riin; Kirillov, Silvia; Kaasik, Allen; Moons, Lieve; De Groef, Lies; Terasmaa, Anton; Vasar, Eero; Plaas, Mario.

Afiliação

Punapart M; Laboratory Animal Centre, Institute of Biomedicine and Translational Medicine, University of Tartu, 14B Ravila Street, 50411 Tartu, Estonia.
Seppa K; Laboratory Animal Centre, Institute of Biomedicine and Translational Medicine, University of Tartu, 14B Ravila Street, 50411 Tartu, Estonia.
Jagomäe T; Department of Physiology, Institute of Biomedicine and Translational Medicine, University of Tartu, 19 Ravila Street, 50411 Tartu, Estonia.
Liiv M; Laboratory Animal Centre, Institute of Biomedicine and Translational Medicine, University of Tartu, 14B Ravila Street, 50411 Tartu, Estonia.
Reimets R; Department of Physiology, Institute of Biomedicine and Translational Medicine, University of Tartu, 19 Ravila Street, 50411 Tartu, Estonia.
Kirillov S; Department of Pharmacology, Institute of Biomedicine and Translational Medicine, University of Tartu, 19 Ravila Street, 50411 Tartu, Estonia.
Kaasik A; Laboratory Animal Centre, Institute of Biomedicine and Translational Medicine, University of Tartu, 14B Ravila Street, 50411 Tartu, Estonia.
Moons L; Laboratory Animal Centre, Institute of Biomedicine and Translational Medicine, University of Tartu, 14B Ravila Street, 50411 Tartu, Estonia.
De Groef L; Department of Pharmacology, Institute of Biomedicine and Translational Medicine, University of Tartu, 19 Ravila Street, 50411 Tartu, Estonia.
Terasmaa A; Research Group Neural Circuit Development and Regeneration, Department of Biology, University of Leuven, Naamsestraat 61, Box 2464, 3000 Leuven, Belgium.
Vasar E; Research Group Neural Circuit Development and Regeneration, Department of Biology, University of Leuven, Naamsestraat 61, Box 2464, 3000 Leuven, Belgium.
Plaas M; Laboratory Animal Centre, Institute of Biomedicine and Translational Medicine, University of Tartu, 14B Ravila Street, 50411 Tartu, Estonia.

Genes (Basel) ; 12(11)2021 10 28.

Article em En | MEDLINE | ID: mdl-34828323

Assuntos

Proteínas de Ligação a Calmodulina/genética; Regulação para Baixo; Proteínas de Membrana/genética; Receptor Tipo 2 de Angiotensina/genética; Receptor B1 da Bradicinina/genética; Síndrome de Wolfram/genética; Aldosterona/sangue; Animais; Células Cultivadas; Modelos Animais de Doenças; Regulação para Baixo/efeitos dos fármacos; Técnicas de Inativação de Genes; Liraglutida/farmacologia; Liraglutida/uso terapêutico; Masculino; Ratos; Sistema Renina-Angiotensina/efeitos dos fármacos; Ácido Valproico/farmacologia; Ácido Valproico/uso terapêutico; Síndrome de Wolfram/sangue; Síndrome de Wolfram/tratamento farmacológico

Palavras-chave

Agtr2; Bdkrb1; RAAS; Wfs1; Wfs1 knock-out; Wolfram syndrome; aldosterone; bradykinin; liraglutide; valproic acid

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome de Wolfram / Proteínas de Ligação a Calmodulina / Regulação para Baixo / Receptor Tipo 2 de Angiotensina / Receptor B1 da Bradicinina / Proteínas de Membrana Limite: Animals Idioma: En Revista: Genes (Basel) Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estônia

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