Recent advances on non-precious metal-catalyzed C-H functionalization of N-heteroarenes.

ABSTRACT

N-Heteroarenes are widely used for numerous medicinal applications, lifesaving drugs and show utmost importance as intermediates in chemical synthesis. This feature article highlights the recent advances, from 2015 to August 2021, on sp2 and sp3 C-H bond functionalization reactions of various N-heteroarenes catalyzed by non-precious transition metals (Mn, Co, Fe, Ni, etc.). The salient features of the report are (i) the development of newer catalysis for Csp2-H activation of N-heteroarenes and categorized into alkylation, alkenylation, borylation, cyanation, and annulation reactions, (ii) recent advances on Csp3-H bond functionalization of N-heteroarenes considering newer approaches for alkylation as well as alkenylation processes, and (iii) synthetic applications and practical utility of the catalytic protocols utilized for late-stage drug development; (iv) scope for the development of newer catalytic protocols along with mechanistic studies and detail mechanistic findings of various important processes.