Dexmedetomidine Promotes Lipopolysaccharide-Induced Differentiation of Cardiac Fibroblasts and Collagen I/III Synthesis through &#945;<sub>2A</sub> Adrenoreceptor-Mediated Activation of the PKC-p38-Smad2/3 Signaling Pathway in Mice.

Liao, Jia; Li, Kaiying; Su, Xingyu; Chen, Yihua; Wang, Yingwei; Tang, Xiangxu; Xing, Yun; Xu, Yaqian; Dai, Xiaomeng; Teng, Jiashuo; Li, Hongmei; Wang, Huadong; Lv, Xiuxiu; Wang, Yiyang

Dexmedetomidine Promotes Lipopolysaccharide-Induced Differentiation of Cardiac Fibroblasts and Collagen I/III Synthesis through α_2A Adrenoreceptor-Mediated Activation of the PKC-p38-Smad2/3 Signaling Pathway in Mice.

Liao, Jia; Li, Kaiying; Su, Xingyu; Chen, Yihua; Wang, Yingwei; Tang, Xiangxu; Xing, Yun; Xu, Yaqian; Dai, Xiaomeng; Teng, Jiashuo; Li, Hongmei; Wang, Huadong; Lv, Xiuxiu; Wang, Yiyang.

Afiliação

Liao J; Department of Pathophysiology, School of Medicine, Jinan University, Guangzhou 510632, China.
Li K; Department of Pathophysiology, School of Medicine, Jinan University, Guangzhou 510632, China.
Su X; Department of Pathophysiology, School of Medicine, Jinan University, Guangzhou 510632, China.
Chen Y; Department of Pathophysiology, School of Medicine, Jinan University, Guangzhou 510632, China.
Wang Y; Department of Pathophysiology, School of Medicine, Jinan University, Guangzhou 510632, China.
Tang X; Department of Pathophysiology, School of Medicine, Jinan University, Guangzhou 510632, China.
Xing Y; Department of Pathophysiology, School of Medicine, Jinan University, Guangzhou 510632, China.
Xu Y; Department of Pathophysiology, School of Medicine, Jinan University, Guangzhou 510632, China.
Dai X; Department of Pathophysiology, School of Medicine, Jinan University, Guangzhou 510632, China.
Teng J; Department of Pathophysiology, School of Medicine, Jinan University, Guangzhou 510632, China.
Li H; Department of Pathophysiology, School of Medicine, Jinan University, Guangzhou 510632, China.
Wang H; Department of Pathophysiology, School of Medicine, Jinan University, Guangzhou 510632, China.
Lv X; Department of Pathophysiology, School of Medicine, Jinan University, Guangzhou 510632, China.
Wang Y; Department of Pathophysiology, School of Medicine, Jinan University, Guangzhou 510632, China.

Int J Mol Sci ; 22(23)2021 Nov 25.

Article em En | MEDLINE | ID: mdl-34884552

Assuntos

Diferenciação Celular; Colágeno Tipo III/metabolismo; Colágeno Tipo I/metabolismo; Dexmedetomidina/farmacologia; Regulação da Expressão Gênica/efeitos dos fármacos; Lipopolissacarídeos/farmacologia; Miofibroblastos/citologia; Receptores Adrenérgicos alfa 2/química; Agonistas de Receptores Adrenérgicos alfa 2/farmacologia; Animais; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Miofibroblastos/efeitos dos fármacos; Miofibroblastos/metabolismo; Proteína Quinase C/genética; Proteína Quinase C/metabolismo; Transdução de Sinais; Proteína Smad2/genética; Proteína Smad2/metabolismo; Proteína Smad3/genética; Proteína Smad3/metabolismo; Proteínas Quinases p38 Ativadas por Mitógeno/genética; Proteínas Quinases p38 Ativadas por Mitógeno/metabolismo

Palavras-chave

cardiac fibroblast; dexmedetomidine; differentiation; lipopolysaccharide; α2 adrenergic receptor

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diferenciação Celular / Regulação da Expressão Gênica / Lipopolissacarídeos / Receptores Adrenérgicos alfa 2 / Dexmedetomidina / Colágeno Tipo I / Colágeno Tipo III / Miofibroblastos Limite: Animals Idioma: En Revista: Int J Mol Sci Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

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