Two novel human coronavirus OC43 genotypes circulating in hospitalized children with pneumonia in China.
Emerg Microbes Infect
; 11(1): 168-171, 2022 Dec.
Article
em En
| MEDLINE
| ID: mdl-34907853
ABSTRACT
HCoV-OC43 is one of the mildly pathogenic coronaviruses with high infection rates in common population. Here, 43 HCoV-OC43 related cases with pneumonia were reported, corresponding genomes of HCoV-OC43 were obtained. Phylogenetic analyses based on complete genome, orf1ab and spike genes revealed that two novel genotypes of HCoV-OC43 have emerged in China. Obvious recombinant events also can be detected in the analysis of the evolutionary dynamics of novel HCoV-OC43 genotypes. Estimated divergence time analysis indicated that the two novel genotypes had apparently independent evolutionary routes. Efforts should be conducted for further investigation of genomic diversity and evolution analysis of mildly pathogenic coronaviruses.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Contexto em Saúde:
1_ASSA2030
Problema de saúde:
1_financiamento_saude
Assunto principal:
Pneumonia Viral
/
Genoma Viral
/
Infecções por Coronavirus
/
Resfriado Comum
/
Coronavirus Humano OC43
/
Genótipo
Tipo de estudo:
Health_economic_evaluation
/
Screening_studies
Limite:
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
País/Região como assunto:
Asia
Idioma:
En
Revista:
Emerg Microbes Infect
Ano de publicação:
2022
Tipo de documento:
Article