Continuous direct compression: Development of an empirical predictive model and challenges regarding PAT implementation.
Int J Pharm X
; 4: 100110, 2022 Dec.
Article
em En
| MEDLINE
| ID: mdl-35024605
#BP, Number of blade passes; #RMB1, Number of radial mixing blades of the main blender; API, Active pharmaceutical ingredient; API_sd, Spray dried API; BRT, Bulk residence time; BU, Blend uniformity; CDC, Continuous direct compression; CDC-50; CU, Content uniformity; C_P, Caffeine anhydrous powder; Continuous direct compression; Continuous manufacturing; DCP, Dicalcium phosphate / Emcompress AN; FD, Fill depth; HM1/HM2, Hold-up mass main blender/Hold-up mass lubricant blender; Imp1, Impeller speed main blender; LC, Percentage label claim; MCF, Main compression force; MCH, Main compression height; MPT_µ, Metoprolol micronized; MgSt, Magnesium stearate/Ligamed MF-2-V; Multivariate data-analysis; NIR, Near infrared; PAT; PAT, Process Analytical Technology; PC, Principle component; PCA, Principle component analysis; PCD, Pre-compression displacement; PCF, Pre-compression force; PCH, Pre-compression height; PH101, Microcrystalline cellulose / Avicel PH-101; PH200, Microcrystalline cellulose / Avicel PH-200; PLS, Partial least squares; P_DP, Paracetamol dense powder; P_P, Paracetamol powder; P_µ, Paracetamol micronized; Predictive modeling; Q2, Goodness of prediction; R2Y, Goodness of fit; RMSEcv, Root mean squared error of cross validation; RSDTW, Relative standard deviation of tablet weight; SD100, Mannitol / Pearlitol 100 SD; T80, Lactose / Tablettose 80; T_P, Theophylline anhydrous powder; rpm, Revolutions per minute; σForce, Main compression force variability; σPCD, Variability in pre-compression displacement
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Int J Pharm X
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Bélgica