Topical therapy with negative allosteric modulators of the calcium-sensing receptor (calcilytics) for the management of asthma: the beginning of a new era?

Riccardi, Daniela; Ward, Jeremy P T; Yarova, Polina L; Janssen, Luke J; Lee, Tak Hong; Ying, Sun; Corrigan, Chris J

Riccardi, Daniela; Ward, Jeremy P T; Yarova, Polina L; Janssen, Luke J; Lee, Tak Hong; Ying, Sun; Corrigan, Chris J.

Afiliação

Riccardi D; Cardiff School of Biosciences, University of Cardiff, Cardiff, UK.
Ward JPT; Faculty of Life Sciences and Medicine and Asthma UK Centre in Allergic Mechanisms of Asthma, King's College London, London, UK.
Yarova PL; Translational and Clinical Research Institute, School of Medical Sciences, Newcastle University, Newcastle, UK.
Janssen LJ; Dept of Medicine, McMaster University, Hamilton, ON, Canada.
Lee TH; Faculty of Life Sciences and Medicine and Asthma UK Centre in Allergic Mechanisms of Asthma, King's College London, London, UK.
Ying S; Hong Kong Sanatorium and Hospital, Hong Kong, China.
Corrigan CJ; Dept of Immunology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.

Eur Respir J ; 60(2)2022 08.

Article em En | MEDLINE | ID: mdl-35058244

ABSTRACT

ABSTRACT

In this review article we present the evidence to date supporting the role of the calcium-sensing receptor (CaSR) as a key, pluripotential molecular trigger for asthma and speculate on the likely benefits of topical therapy of asthma with negative allosteric modulators of the CaSR calcilytics.

Assuntos

Asma; Receptores de Detecção de Cálcio; Asma/tratamento farmacológico; Cálcio; Humanos

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Asma / Receptores de Detecção de Cálcio Limite: Humans Idioma: En Revista: Eur Respir J Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Reino Unido

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