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Heterogenous impairment of α cell function in type 2 diabetes is linked to cell maturation state.
Dai, Xiao-Qing; Camunas-Soler, Joan; Briant, Linford J B; Dos Santos, Theodore; Spigelman, Aliya F; Walker, Emily M; Arrojo E Drigo, Rafael; Bautista, Austin; Jones, Robert C; Avrahami, Dana; Lyon, James; Nie, Aifang; Smith, Nancy; Zhang, Yongneng; Johnson, Janyne; Manning Fox, Jocelyn E; Michelakis, Evangelos D; Light, Peter E; Kaestner, Klaus H; Kim, Seung K; Rorsman, Patrik; Stein, Roland W; Quake, Stephen R; MacDonald, Patrick E.
Afiliação
  • Dai XQ; Department of Pharmacology, University of Alberta, Edmonton, AB T6G2R3, Canada; Alberta Diabetes Institute, University of Alberta, Edmonton, AB T6G2R3, Canada.
  • Camunas-Soler J; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA; Chan Zuckerberg Biohub, San Francisco, CA 94518, USA.
  • Briant LJB; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, Churchill Hospital, Oxford OX3 7LE, UK.
  • Dos Santos T; Department of Pharmacology, University of Alberta, Edmonton, AB T6G2R3, Canada; Alberta Diabetes Institute, University of Alberta, Edmonton, AB T6G2R3, Canada.
  • Spigelman AF; Department of Pharmacology, University of Alberta, Edmonton, AB T6G2R3, Canada; Alberta Diabetes Institute, University of Alberta, Edmonton, AB T6G2R3, Canada.
  • Walker EM; Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48105, USA.
  • Arrojo E Drigo R; Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Bautista A; Alberta Diabetes Institute, University of Alberta, Edmonton, AB T6G2R3, Canada.
  • Jones RC; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.
  • Avrahami D; Endocrinology and Metabolism Department, Hadassah-Hebrew University Medical Centre, Jerusalem, Israel.
  • Lyon J; Alberta Diabetes Institute, University of Alberta, Edmonton, AB T6G2R3, Canada.
  • Nie A; Department of Pharmacology, University of Alberta, Edmonton, AB T6G2R3, Canada; Alberta Diabetes Institute, University of Alberta, Edmonton, AB T6G2R3, Canada.
  • Smith N; Department of Pharmacology, University of Alberta, Edmonton, AB T6G2R3, Canada; Alberta Diabetes Institute, University of Alberta, Edmonton, AB T6G2R3, Canada.
  • Zhang Y; Department of Medicine, University of Alberta, Edmonton, AB T6G2R3, Canada.
  • Johnson J; Department of Pharmacology, University of Alberta, Edmonton, AB T6G2R3, Canada; Alberta Diabetes Institute, University of Alberta, Edmonton, AB T6G2R3, Canada.
  • Manning Fox JE; Department of Pharmacology, University of Alberta, Edmonton, AB T6G2R3, Canada; Alberta Diabetes Institute, University of Alberta, Edmonton, AB T6G2R3, Canada.
  • Michelakis ED; Department of Medicine, University of Alberta, Edmonton, AB T6G2R3, Canada.
  • Light PE; Department of Pharmacology, University of Alberta, Edmonton, AB T6G2R3, Canada; Alberta Diabetes Institute, University of Alberta, Edmonton, AB T6G2R3, Canada.
  • Kaestner KH; Department of Genetics and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Kim SK; Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA; Stanford Diabetes Research Center, Stanford University, Stanford, CA 94305, USA.
  • Rorsman P; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, Churchill Hospital, Oxford OX3 7LE, UK.
  • Stein RW; Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Quake SR; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA; Chan Zuckerberg Biohub, San Francisco, CA 94518, USA; Department of Applied Physics, Stanford University, Stanford, CA 94305, USA.
  • MacDonald PE; Department of Pharmacology, University of Alberta, Edmonton, AB T6G2R3, Canada; Alberta Diabetes Institute, University of Alberta, Edmonton, AB T6G2R3, Canada. Electronic address: pmacdonald@ualberta.ca.
Cell Metab ; 34(2): 256-268.e5, 2022 02 01.
Article em En | MEDLINE | ID: mdl-35108513
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ilhotas Pancreáticas / Diabetes Mellitus Tipo 2 / Células Secretoras de Glucagon Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Cell Metab Assunto da revista: METABOLISMO Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Canadá
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ilhotas Pancreáticas / Diabetes Mellitus Tipo 2 / Células Secretoras de Glucagon Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Cell Metab Assunto da revista: METABOLISMO Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Canadá