Calcium Enabled Remote Loading of a Weak Acid Into pH-sensitive Liposomes and Augmented Cytosolic Delivery to Cancer Cells via the Proton Sponge Effect.

Yang, Mimi M; Yarragudi, Sasi Bhushan; Jamieson, Stephen M F; Tang, Mingtan; Wilson, William R; Wu, Zimei

Yang, Mimi M; Yarragudi, Sasi Bhushan; Jamieson, Stephen M F; Tang, Mingtan; Wilson, William R; Wu, Zimei.

Afiliação

Yang MM; School of Pharmacy, The University of Auckland, Auckland, 1142, New Zealand.
Yarragudi SB; School of Pharmacy, The University of Auckland, Auckland, 1142, New Zealand.
Jamieson SMF; Auckland Cancer Society Research Centre, The University of Auckland, Auckland, New Zealand.
Tang M; School of Pharmacy, The University of Auckland, Auckland, 1142, New Zealand.
Wilson WR; Auckland Cancer Society Research Centre, The University of Auckland, Auckland, New Zealand.
Wu Z; School of Pharmacy, The University of Auckland, Auckland, 1142, New Zealand. z.wu@auckland.ac.nz.

Pharm Res ; 39(6): 1181-1195, 2022 Jun.

Article em En | MEDLINE | ID: mdl-35229237

Assuntos

Lipossomos; Neoplasias; Animais; Cálcio; Linhagem Celular Tumoral; Sistemas de Liberação de Medicamentos; Endossomos; Concentração de Íons de Hidrogênio; Lipossomos/farmacologia; Camundongos; Prótons

Palavras-chave

Calcium acetate; Co-localization analysis; Cytosolic delivery; Endosomal entrapment; Proton sponge effect; Remote drug loading; pH-sensitive liposomes

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Lipossomos / Neoplasias Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals Idioma: En Revista: Pharm Res Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Nova Zelândia

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