Promethazine Downregulates Wnt/ß-Catenin Signaling and Increases the Biomechanical Forces of the Injured Achilles Tendon in the Early Stage of Healing.

Sakaguchi, Takefumi; Ohkawara, Bisei; Kishimoto, Yasuzumi; Miyamoto, Kentaro; Ishizuka, Shinya; Hiraiwa, Hideki; Ishiguro, Naoki; Imagama, Shiro; Ohno, Kinji

Sakaguchi, Takefumi; Ohkawara, Bisei; Kishimoto, Yasuzumi; Miyamoto, Kentaro; Ishizuka, Shinya; Hiraiwa, Hideki; Ishiguro, Naoki; Imagama, Shiro; Ohno, Kinji.

Afiliação

Sakaguchi T; Division of Neurogenetics, Center for Neurological Diseases and Cancer, Graduate School of Medicine, Nagoya University, Nagoya, Japan.
Ohkawara B; Department of Orthopaedic Surgery, Graduate School of Medicine, Nagoya University, Nagoya, Japan.
Kishimoto Y; Division of Neurogenetics, Center for Neurological Diseases and Cancer, Graduate School of Medicine, Nagoya University, Nagoya, Japan.
Miyamoto K; Division of Neurogenetics, Center for Neurological Diseases and Cancer, Graduate School of Medicine, Nagoya University, Nagoya, Japan.
Ishizuka S; Department of Orthopaedic Surgery, Graduate School of Medicine, Nagoya University, Nagoya, Japan.
Hiraiwa H; Division of Neurogenetics, Center for Neurological Diseases and Cancer, Graduate School of Medicine, Nagoya University, Nagoya, Japan.
Ishiguro N; Department of Orthopaedic Surgery, Graduate School of Medicine, Nagoya University, Nagoya, Japan.
Imagama S; Department of Orthopaedic Surgery, Graduate School of Medicine, Nagoya University, Nagoya, Japan.
Ohno K; Department of Orthopaedic Surgery, Graduate School of Medicine, Nagoya University, Nagoya, Japan.

Am J Sports Med ; 50(5): 1317-1327, 2022 04.

Article em En | MEDLINE | ID: mdl-35234523

Assuntos

Tendão do Calcâneo; Prometazina; Tendão do Calcâneo/lesões; Animais; Fenômenos Biomecânicos; Humanos; Prometazina/metabolismo; Prometazina/farmacologia; Ratos; Ratos Sprague-Dawley; Via de Sinalização Wnt; Cicatrização/fisiologia; beta Catenina/metabolismo; beta Catenina/farmacologia

Palavras-chave

Achilles tendon; biomechanics of the tendon; drug repositioning; promethazine; tendon healing

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Prometazina / Tendão do Calcâneo Limite: Animals / Humans Idioma: En Revista: Am J Sports Med Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Japão

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