Prediction of tissue and urine concentrations of 2-phenoxyethanol and its metabolite 2-phenoxyacetic acid in rat and human after oral and dermal exposures via GastroPlus<sup>TM</sup> physiologically based pharmacokinetic modelling.

Zhang, F; LeBaron, M J; Marty, M S

Prediction of tissue and urine concentrations of 2-phenoxyethanol and its metabolite 2-phenoxyacetic acid in rat and human after oral and dermal exposures via GastroPlus^TM physiologically based pharmacokinetic modelling.

Zhang, F; LeBaron, M J; Marty, M S.

Afiliação

Zhang F; Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Midland, MI, USA.
LeBaron MJ; Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Midland, MI, USA.
Marty MS; Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Midland, MI, USA.

SAR QSAR Environ Res ; 33(5): 323-339, 2022 May.

Article em En | MEDLINE | ID: mdl-35301938

Assuntos

Modelos Biológicos; Relação Quantitativa Estrutura-Atividade; Acetatos; Animais; Etilenoglicóis/farmacocinética; Humanos; Ratos

Palavras-chave

GastroPlusTM; PBPK; margin of exposure (MOE); phenoxyacetic acid; phenoxyethanol

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Relação Quantitativa Estrutura-Atividade / Modelos Biológicos Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: SAR QSAR Environ Res Assunto da revista: SAUDE AMBIENTAL Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos

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