Aortic valve intervention for aortic stenosis and cardiac amyloidosis: a systematic review and meta-analysis.

Dual presentation of aortic stenosis (AS) and cardiac amyloidosis (CA) is common in the elderly. Patients with CA-AS face a dismal prognosis. Clinical outcomes after an aortic valve intervention are conflicting. Our data showed that there is no increased risk of death in CA-AS patients compared with patients with only AS after an aortic valve replacement. In particular, our analysis unveils that following less invasive percutaneous aortic valve replacement, rates of death of patients with concomitant CA were not significantly different from those in patients who had AS without CA. Based on this data, an aortic valve substitution procedure should not be withheld in patients with CA.