Long-term Weight Change and its Temporal Relation to Later-life Dementia in the Health and Retirement Study.
J Clin Endocrinol Metab
; 107(7): e2710-e2716, 2022 06 16.
Article
em En
| MEDLINE
| ID: mdl-35420682
ABSTRACT
CONTEXT Weight loss among middle-aged and older adults has been associated with a higher risk of subsequent dementia. However, most studies have limited follow-up durations or suboptimal control for the potential influence of physical frailty (PF). OBJECTIVE:
Our study aimed to investigate the long-term and temporal relations of weight change to risk of dementia among middle-aged and older adults in the United States.METHODS:
A total of 5985 participants aged 65 years and older were included from the Health and Retirement Study. History of long-term weight change was calculated using 9 repeated body mass index measurements during 1992-2008. We then followed participants' dementia status from 2008 to 2018. Multivariable Cox proportional hazard models were used.RESULTS:
During the study follow-up period (meanâ =â 7.54 years), a total of 682 (11.40%) dementia cases were documented. After adjustment for basic demographic and lifestyle factors, participants with weight loss (median -0.23 kg/m2 per year) were at a significantly higher risk of dementia (HRâ =â 1.60; 95% CI, 1.33, 1.92), compared with the stable weight group (median 0.11 kg/m2 per year). This association was attenuated but remained strong and significant after further adjustment for PF (HRâ =â 1.57; 95% CI, 1.30, 1.89). Significant association was observed for weight loss assessed approximately 14 to 18 years preceding dementia diagnosis (HRâ =â 1.30; 95% CI, 1.07, 1.58), and was consistent closer to diagnosis.CONCLUSION:
Both recent and remote weight loss were associated with a higher risk of later-life dementia among middle-aged and older adults independent of PF status.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Demência
/
Fragilidade
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Aspecto:
Patient_preference
Limite:
Aged
/
Humans
/
Middle aged
País/Região como assunto:
America do norte
Idioma:
En
Revista:
J Clin Endocrinol Metab
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
China