SCP-7, a germacrane-type sesquiterpene lactone derivative, induces ROS-mediated apoptosis in NSCLC cells in vitro and in vivo.

Zhang, Yang-Yang; Ren, Hui; Yan, Qiu-Lin; Li, Ya-Ling; Liu, Qingbo; Yao, Guo-Dong; Song, Shao-Jiang

Zhang, Yang-Yang; Ren, Hui; Yan, Qiu-Lin; Li, Ya-Ling; Liu, Qingbo; Yao, Guo-Dong; Song, Shao-Jiang.

Afiliação

Zhang YY; Key Laboratory of Computational Chemistry Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, PR China.
Ren H; Key Laboratory of Computational Chemistry Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, PR China.
Yan QL; Key Laboratory of Computational Chemistry Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, PR China.
Li YL; Key Laboratory of Computational Chemistry Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, PR China.
Liu Q; Key Laboratory of Computational Chemistry Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, PR China. Electronic address: liuqingbolily@163.com.
Yao GD; Key Laboratory of Computational Chemistry Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, PR China. Electronic address: guodong_yao@126.com.
Song SJ; Key Laboratory of Computational Chemistry Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, PR China. Electronic address: songsj99@163.com.

Eur J Pharmacol ; 925: 174989, 2022 Jun 15.

Article em En | MEDLINE | ID: mdl-35490722

Assuntos

Antineoplásicos; Carcinoma Pulmonar de Células não Pequenas; Neoplasias Pulmonares; Antineoplásicos/farmacologia; Antineoplásicos/uso terapêutico; Apoptose; Carcinoma Pulmonar de Células não Pequenas/tratamento farmacológico; Carcinoma Pulmonar de Células não Pequenas/patologia; Linhagem Celular Tumoral; Humanos; Lactonas/farmacologia; Lactonas/uso terapêutico; Neoplasias Pulmonares/patologia; Simulação de Acoplamento Molecular; Compostos Fitoquímicos/farmacologia; Espécies Reativas de Oxigênio/metabolismo; Sesquiterpenos de Germacrano/farmacologia; Sesquiterpenos de Germacrano/uso terapêutico

Palavras-chave

Mitochondrial apoptosis; Non-small cell lung cancer; SCP-7; Sesquiterpene lactones; Structural modification

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Contexto em Saúde: 6_ODS3_enfermedades_notrasmisibles Problema de saúde: 6_other_respiratory_diseases / 6_trachea_bronchus_lung_cancer Assunto principal: Carcinoma Pulmonar de Células não Pequenas / Neoplasias Pulmonares / Antineoplásicos Limite: Humans Idioma: En Revista: Eur J Pharmacol Ano de publicação: 2022 Tipo de documento: Article

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