Copper-catalysed enantioselective intramolecular etherification of propargylic esters: synthetic approach to chiral isochromans.

Liu, Shiyao; Nakajima, Kazunari; Nishibayashi, Yoshiaki

Liu, Shiyao; Nakajima, Kazunari; Nishibayashi, Yoshiaki.

Afiliação

Liu S; Department of Systems Innovation, School of Engineering, The University of Tokyo Hongo Bunkyo-ku Tokyo 113-8656 Japan ynishiba@sys.t.u-tokyo.ac.jp.
Nakajima K; Frontier Research Centre for Energy and Resources, School of Engineering, The University of Tokyo Hongo Bunkyo-ku Tokyo 113-8656 Japan.
Nishibayashi Y; Department of Systems Innovation, School of Engineering, The University of Tokyo Hongo Bunkyo-ku Tokyo 113-8656 Japan ynishiba@sys.t.u-tokyo.ac.jp.

RSC Adv ; 9(33): 18918-18922, 2019 Jun 14.

Article em En | MEDLINE | ID: mdl-35516894

ABSTRACT

ABSTRACT

Enantioselective synthesis of chiral isochromans bearing a terminal alkyne moiety has been accomplished by copper-catalysed enantioselective intramolecular propargylic substitution reactions of propargylic esters with alcoholic nucleophiles. This method represents the first successful example which directly introduced a terminal alkyne group into chiral isochromans.

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: RSC Adv Ano de publicação: 2019 Tipo de documento: Article