Spatial quantification of clinical biomarker pharmacokinetics through deep learning-based segmentation and signal-oriented analysis of MSOT data.

Hoffmann, Bianca; Gerst, Ruman; Cseresnyés, Zoltán; Foo, WanLing; Sommerfeld, Oliver; Press, Adrian T; Bauer, Michael; Figge, Marc Thilo

Hoffmann, Bianca; Gerst, Ruman; Cseresnyés, Zoltán; Foo, WanLing; Sommerfeld, Oliver; Press, Adrian T; Bauer, Michael; Figge, Marc Thilo.

Afiliação

Hoffmann B; Research Group Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute (HKI), Beutenbergstr. 11a, 07745 Jena, Germany.
Gerst R; Research Group Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute (HKI), Beutenbergstr. 11a, 07745 Jena, Germany.
Cseresnyés Z; Faculty of Biological Sciences, Friedrich Schiller University Jena, Bachstr. 18k, 07743 Jena, Germany.
Foo W; Research Group Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute (HKI), Beutenbergstr. 11a, 07745 Jena, Germany.
Sommerfeld O; Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Am Klinikum 1, 07747 Jena, Germany.
Press AT; Center for Sepsis Control and Care, Jena University Hospital, Am Klinikum 1, 07747 Jena, Germany.
Bauer M; Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Am Klinikum 1, 07747 Jena, Germany.
Figge MT; Center for Sepsis Control and Care, Jena University Hospital, Am Klinikum 1, 07747 Jena, Germany.

Photoacoustics ; 26: 100361, 2022 Jun.

Article em En | MEDLINE | ID: mdl-35541023

Palavras-chave

AUC, Area under the curve; Biomarkers; DAG, Directed acyclic graph; DL, Deep learning; Deep learning; GUI, Graphical user interface; ICG, Indocyanine green; ImageJ plugin; MSE, Mean squared error; MSOT, Multispectral optoacoustic tomography; Mcat, MSOT cluster analysis toolkit; Multispectral optoacoustic tomography; PCI, Peritoneal contamination and infection; Pharmacokinetics; Quantitative image analysis; ROI, Region of interest; Sepsis; WAC, Weighted-average curve

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Photoacoustics Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Alemanha

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