Blockade of mIL-6R alleviated lipopolysaccharide-induced systemic inflammatory response syndrome by suppressing NF-&#954;B-mediated Ccl2 expression and inflammasome activation.

Dai, Ji-Min; Zhang, Xue-Qin; Zhang, Jia-Jia; Yang, Wei-Jie; Yang, Xiang-Min; Bian, Huijie; Chen, Zhi-Nan

Blockade of mIL-6R alleviated lipopolysaccharide-induced systemic inflammatory response syndrome by suppressing NF-κB-mediated Ccl2 expression and inflammasome activation.

Dai, Ji-Min; Zhang, Xue-Qin; Zhang, Jia-Jia; Yang, Wei-Jie; Yang, Xiang-Min; Bian, Huijie; Chen, Zhi-Nan.

Afiliação

Dai JM; National Translational Science Center for Molecular Medicine&Department of Cell Biology State Key Laboratory of Cancer Biology the Fourth Military Medical University Xi'an P.R. China.
Zhang XQ; Faculty of Hepato-Biliary-Pancreatic Surgery The First Medical Center of Chinese People's Liberation Army (PLA) General Hospital Beijing P.R. China.
Zhang JJ; National Translational Science Center for Molecular Medicine&Department of Cell Biology State Key Laboratory of Cancer Biology the Fourth Military Medical University Xi'an P.R. China.
Yang WJ; National Translational Science Center for Molecular Medicine&Department of Cell Biology State Key Laboratory of Cancer Biology the Fourth Military Medical University Xi'an P.R. China.
Yang XM; National Translational Science Center for Molecular Medicine&Department of Cell Biology State Key Laboratory of Cancer Biology the Fourth Military Medical University Xi'an P.R. China.
Bian H; National Translational Science Center for Molecular Medicine&Department of Cell Biology State Key Laboratory of Cancer Biology the Fourth Military Medical University Xi'an P.R. China.
Chen ZN; National Translational Science Center for Molecular Medicine&Department of Cell Biology State Key Laboratory of Cancer Biology the Fourth Military Medical University Xi'an P.R. China.

MedComm (2020) ; 3(2): e132, 2022 Jun.

Article em En | MEDLINE | ID: mdl-35548710

Palavras-chave

Ccl2; NFκB; SIRS; mIL6R; monoclonal antibody; pyroptosis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: MedComm (2020) Ano de publicação: 2022 Tipo de documento: Article