A novel nonlinear afterload for ex vivo heart evaluation: Porcine experimental results.
Artif Organs
; 46(9): 1794-1803, 2022 Sep.
Article
em En
| MEDLINE
| ID: mdl-35548921
ABSTRACT
BACKGROUND:
Existing working heart models for ex vivo functional evaluation of donor hearts often use cardiac afterloads made up of discrete resistive and compliant elements. This approach limits the practicality of independently controlling systolic and diastolic aortic pressure to safely test the heart under multiple loading conditions. We present and investigate a novel afterload concept designed to enable such control.METHODS:
Six â¼70 kg pig hearts were evaluated in vivo, then ex vivo in left-ventricular working mode using the presented afterload. Both in vivo and ex vivo, the hearts were evaluated at two exertion levels at rest and following a 20 µg adrenaline bolus, while measuring aortic pressure and flow, left ventricular pressure and volume, and left atrial pressure.RESULTS:
The afterload gave aortic pressure waveforms that matched the general shape of the in vivo measurements. A wide range of physiological systolic pressures (93 to 160 mm Hg) and diastolic pressures (73 to 113 mm Hg) were generated by the afterload.CONCLUSIONS:
With the presented afterload concept, multiple physiological loading conditions could be tested ex vivo, and compared with the corresponding in vivo data. An additional control loop from the set pressure limits to the measured systolic and diastolic aortic pressure is proposed to address discrepancies observed between the set limits and the measured pressures.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transplante de Coração
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Artif Organs
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Suécia