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Azetidin-2-one-based small molecules as dual hHDAC6/HDAC8 inhibitors: Investigation of their mechanism of action and impact of dual inhibition profile on cell viability.
Federico, Stefano; Khan, Tuhina; Fontana, Anna; Brogi, Simone; Benedetti, Rosaria; Sarno, Federica; Carullo, Gabriele; Pezzotta, Alex; Saraswati, Akella Prasanth; Passaro, Eugenia; Pozzetti, Luca; Papa, Alessandro; Relitti, Nicola; Gemma, Sandra; Butini, Stefania; Pistocchi, Anna; Ramunno, Anna; Vincenzi, Fabrizio; Varani, Katia; Tatangelo, Vanessa; Patrussi, Laura; Baldari, Cosima T; Saponara, Simona; Gorelli, Beatrice; Lamponi, Stefania; Valoti, Massimo; Saccoccia, Fulvio; Giannaccari, Marialaura; Ruberti, Giovina; Herp, Daniel; Jung, Manfred; Altucci, Lucia; Campiani, Giuseppe.
Afiliação
  • Federico S; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, 53100, Siena, Italy.
  • Khan T; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, 53100, Siena, Italy.
  • Fontana A; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, 53100, Siena, Italy.
  • Brogi S; Department of Pharmacy, University of Pisa, 56126, Pisa, Italy.
  • Benedetti R; Department of Precision Medicine, University of Campania Luigi Vanvitelli, 80138, Naples, Italy.
  • Sarno F; Department of Precision Medicine, University of Campania Luigi Vanvitelli, 80138, Naples, Italy.
  • Carullo G; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, 53100, Siena, Italy.
  • Pezzotta A; Department of Medical Biotechnology and Translational Medicine, University of Milan, LITA - Via Fratelli Cervi 93, 20090, Segrate (MI), Italy.
  • Saraswati AP; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, 53100, Siena, Italy.
  • Passaro E; Department of Precision Medicine, University of Campania Luigi Vanvitelli, 80138, Naples, Italy.
  • Pozzetti L; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, 53100, Siena, Italy.
  • Papa A; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, 53100, Siena, Italy.
  • Relitti N; IRBM Science Park, Via Pontina Km 30,600, 00071, Pomezia, Rome, Italy.
  • Gemma S; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, 53100, Siena, Italy.
  • Butini S; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, 53100, Siena, Italy.
  • Pistocchi A; Department of Medical Biotechnology and Translational Medicine, University of Milan, LITA - Via Fratelli Cervi 93, 20090, Segrate (MI), Italy.
  • Ramunno A; Department of Pharmacy, University of Salerno, 84084, Fisciano (SA), Italy.
  • Vincenzi F; Department of Translational Medicine, University of Ferrara, 44121, Ferrara, Italy.
  • Varani K; Department of Translational Medicine, University of Ferrara, 44121, Ferrara, Italy.
  • Tatangelo V; Department of Life Sciences, University of Siena, 53100, Siena, Italy.
  • Patrussi L; Department of Life Sciences, University of Siena, 53100, Siena, Italy.
  • Baldari CT; Department of Life Sciences, University of Siena, 53100, Siena, Italy.
  • Saponara S; Department of Life Sciences, University of Siena, 53100, Siena, Italy.
  • Gorelli B; Department of Life Sciences, University of Siena, 53100, Siena, Italy.
  • Lamponi S; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, 53100, Siena, Italy.
  • Valoti M; Department of Life Sciences, University of Siena, 53100, Siena, Italy.
  • Saccoccia F; Institute of Biochemistry and Cell Biology (IBBC), National Research Council (CNR), 00015, Monterotondo, (Rome), Italy.
  • Giannaccari M; Institute of Biochemistry and Cell Biology (IBBC), National Research Council (CNR), 00015, Monterotondo, (Rome), Italy.
  • Ruberti G; Institute of Biochemistry and Cell Biology (IBBC), National Research Council (CNR), 00015, Monterotondo, (Rome), Italy.
  • Herp D; Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universität Freiburg, 79104, Freiburg, Germany.
  • Jung M; Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universität Freiburg, 79104, Freiburg, Germany.
  • Altucci L; Department of Precision Medicine, University of Campania Luigi Vanvitelli, 80138, Naples, Italy; BIOGEM, Molecular Biology and Genetics Research Institute, Ariano Irpino (AV), Italy. Electronic address: lucia.altucci@unicampania.it.
  • Campiani G; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, 53100, Siena, Italy. Electronic address: campiani@unisi.it.
Eur J Med Chem ; 238: 114409, 2022 Aug 05.
Article em En | MEDLINE | ID: mdl-35551034
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores de Histona Desacetilases / Ácidos Hidroxâmicos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Itália
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores de Histona Desacetilases / Ácidos Hidroxâmicos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Itália