Photoaffinity labeling of benzophenone-containing salicylanilide compounds to give an insight into the mechanism in disrupting peptidoglycan formation.

Chuang, Hao-Chun; Liu, Ming-Fang; Wu, Hsin-Yi; Wu, Ying-Ta; Cheng, Ting-Jen Rachel; Fang, Jim-Min

Chuang, Hao-Chun; Liu, Ming-Fang; Wu, Hsin-Yi; Wu, Ying-Ta; Cheng, Ting-Jen Rachel; Fang, Jim-Min.

Afiliação

Chuang HC; Department of Chemistry, National Taiwan University, Taipei 106, Taiwan, ROC.
Liu MF; Department of Chemistry, National Taiwan University, Taipei 106, Taiwan, ROC.
Wu HY; Instrumentation Center, College of Science, National Taiwan University, Taipei 106, Taiwan, ROC.
Wu YT; The Genomics Research Center, Academia Sinica, Taipei 115, Taiwan, ROC.
Cheng TR; The Genomics Research Center, Academia Sinica, Taipei 115, Taiwan, ROC.
Fang JM; Department of Chemistry, National Taiwan University, Taipei 106, Taiwan, ROC; The Genomics Research Center, Academia Sinica, Taipei 115, Taiwan, ROC. Electronic address: jmfang@ntu.edu.tw.

Bioorg Med Chem ; 67: 116819, 2022 08 01.

Article em En | MEDLINE | ID: mdl-35635930

Assuntos

Peptidoglicano Glicosiltransferase; Benzofenonas/farmacologia; Escherichia coli/metabolismo; Simulação de Acoplamento Molecular; Peptidoglicano; Peptidoglicano Glicosiltransferase/química; Peptidoglicano Glicosiltransferase/metabolismo; Marcadores de Fotoafinidade; Salicilanilidas; Espectrometria de Massas em Tandem

Palavras-chave

Antibacterial agent; Molecular docking; Peptidoglycan; Photoaffinity labeling; Salicylanilide compound

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Contexto em Saúde: 3_ND Problema de saúde: 3_neglected_diseases / 3_zoonosis Assunto principal: Peptidoglicano Glicosiltransferase Idioma: En Revista: Bioorg Med Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2022 Tipo de documento: Article

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