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Limited nutrient availability in the tumor microenvironment renders pancreatic tumors sensitive to allosteric IDH1 inhibitors.
Vaziri-Gohar, Ali; Cassel, Joel; Mohammed, Farheen S; Zarei, Mehrdad; Hue, Jonathan J; Hajihassani, Omid; Graor, Hallie J; Srikanth, Yellamelli V V; Karim, Saadia A; Abbas, Ata; Prendergast, Erin; Chen, Vanessa; Katayama, Erryk S; Dukleska, Katerina; Khokhar, Imran; Andren, Anthony; Zhang, Li; Wu, Chunying; Erokwu, Bernadette; Flask, Chris A; Zarei, Mahsa; Wang, Rui; Rothermel, Luke D; Romani, Andrea M P; Bowers, Jessica; Getts, Robert; Tatsuoka, Curtis; Morton, Jennifer P; Bederman, Ilya; Brunengraber, Henri; Lyssiotis, Costas A; Salvino, Joseph M; Brody, Jonathan R; Winter, Jordan M.
Afiliação
  • Vaziri-Gohar A; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA.
  • Cassel J; Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA, USA.
  • Mohammed FS; Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA, USA.
  • Zarei M; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA.
  • Hue JJ; Department of Surgery, Division of Surgical Oncology, University Hospitals, Cleveland Medical Center, Cleveland, OH, USA.
  • Hajihassani O; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA.
  • Graor HJ; Department of Surgery, Division of Surgical Oncology, University Hospitals, Cleveland Medical Center, Cleveland, OH, USA.
  • Srikanth YVV; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA.
  • Karim SA; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA.
  • Abbas A; Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA, USA.
  • Prendergast E; Cancer Research UK Beatson Institute, Glasgow, UK.
  • Chen V; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA.
  • Katayama ES; Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA.
  • Dukleska K; Department of Nutrition, Case Western Reserve University, Cleveland, OH, USA.
  • Khokhar I; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA.
  • Andren A; Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA.
  • Zhang L; Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA.
  • Wu C; Department of Molecular and Integrative Physiology, University of Michigan School of Medicine, Ann Arbor, MI, USA.
  • Erokwu B; Department of Molecular and Integrative Physiology, University of Michigan School of Medicine, Ann Arbor, MI, USA.
  • Flask CA; Department of Radiology, Case Western Reserve University, Cleveland, OH, USA.
  • Zarei M; Department of Radiology, Case Western Reserve University, Cleveland, OH, USA.
  • Wang R; Deptartments of Radiology, Biomedical Engineering, and Pediatrics, Case Western Reserve University, Cleveland, OH, USA.
  • Rothermel LD; Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, TX, USA.
  • Romani AMP; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA.
  • Bowers J; Department of Surgery, Division of Surgical Oncology, University Hospitals, Cleveland Medical Center, Cleveland, OH, USA.
  • Getts R; Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, USA.
  • Tatsuoka C; Code Biotherapeutics Inc, Hatfield, PA, USA.
  • Morton JP; Code Biotherapeutics Inc, Hatfield, PA, USA.
  • Bederman I; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.
  • Brunengraber H; Cancer Research UK Beatson Institute, Glasgow, UK.
  • Lyssiotis CA; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK.
  • Salvino JM; Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA.
  • Brody JR; Department of Nutrition and Biochemistry, Case Western Reserve University, Cleveland, OH, USA.
  • Winter JM; Department of Molecular and Integrative Physiology, University of Michigan School of Medicine, Ann Arbor, MI, USA.
Nat Cancer ; 3(7): 852-865, 2022 07.
Article em En | MEDLINE | ID: mdl-35681100
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Isocitrato Desidrogenase Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Revista: Nat Cancer Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Isocitrato Desidrogenase Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Revista: Nat Cancer Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos