A preliminary investigation into the use of amino acids as potential ion pairs for diclofenac transdermal delivery.

Cristofoli, Mignon; Hadgraft, Jonathan; Lane, Majella E; Sil, Bruno C

Cristofoli, Mignon; Hadgraft, Jonathan; Lane, Majella E; Sil, Bruno C.

Afiliação

Cristofoli M; School of Human Sciences, London Metropolitan University, 166 - 220 Holloway Road, London N7 8DB, UK. Electronic address: mic0501@my.londonmet.ac.uk.
Hadgraft J; School of Pharmacy, University College London, 29 - 39 Brunswick Square, London WC1N 1AX, UK. Electronic address: jonathan.hadgraft@btinternet.com.
Lane ME; School of Pharmacy, University College London, 29 - 39 Brunswick Square, London WC1N 1AX, UK. Electronic address: m.lane@ucl.ac.uk.
Sil BC; School of Human Sciences, London Metropolitan University, 166 - 220 Holloway Road, London N7 8DB, UK. Electronic address: b.dasilvasildossantos@londonmet.ac.uk.

Int J Pharm ; 623: 121906, 2022 Jul 25.

Article em En | MEDLINE | ID: mdl-35716976

Assuntos

Aminoácidos; Diclofenaco; Ácidos; Administração Cutânea; Aminoácidos/metabolismo; Animais; Íons/química; Pele/metabolismo; Suínos

Palavras-chave

Amino acids; Diclofenac; Diclofenac sodium; Ion pairs; Mass balance; Partition coefficient studies; Permeation; Porcine skin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diclofenaco / Aminoácidos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Int J Pharm Ano de publicação: 2022 Tipo de documento: Article

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