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OX2R-selective orexin agonism is sufficient to ameliorate cataplexy and sleep/wake fragmentation without inducing drug-seeking behavior in mouse model of narcolepsy.
Yamamoto, Hikari; Nagumo, Yasuyuki; Ishikawa, Yukiko; Irukayama-Tomobe, Yoko; Namekawa, Yukiko; Nemoto, Tsuyoshi; Tanaka, Hiromu; Takahashi, Genki; Tokuda, Akihisa; Saitoh, Tsuyoshi; Nagase, Hiroshi; Funato, Hiromasa; Yanagisawa, Masashi.
Afiliação
  • Yamamoto H; International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Ibaraki, Japan.
  • Nagumo Y; International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Ibaraki, Japan.
  • Ishikawa Y; International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Ibaraki, Japan.
  • Irukayama-Tomobe Y; International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Ibaraki, Japan.
  • Namekawa Y; International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Ibaraki, Japan.
  • Nemoto T; School of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
  • Tanaka H; School of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
  • Takahashi G; School of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
  • Tokuda A; International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Ibaraki, Japan.
  • Saitoh T; International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Ibaraki, Japan.
  • Nagase H; International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Ibaraki, Japan.
  • Funato H; International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Ibaraki, Japan.
  • Yanagisawa M; Department of Anatomy, Faculty of Medicine, Toho University, Ota-ku, Tokyo, Japan.
PLoS One ; 17(7): e0271901, 2022.
Article em En | MEDLINE | ID: mdl-35867683
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cataplexia / Narcolepsia Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Japão
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cataplexia / Narcolepsia Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Japão