Calcium/calmodulin-dependent protein kinase II&#945; heterozygous knockout mice show electroencephalogram and behavioral changes characteristic of a subpopulation of schizophrenia and intellectual impairment.

Featherstone, Robert E; Shimada, Takeshi; Crown, Lindsey M; Melnychenko, Olya; Yi, Janice; Matsumoto, Mitsuyuki; Tajinda, Katsunori; Mihara, Takuma; Adachi, Megumi; Siegel, Steven J

Calcium/calmodulin-dependent protein kinase IIα heterozygous knockout mice show electroencephalogram and behavioral changes characteristic of a subpopulation of schizophrenia and intellectual impairment.

Featherstone, Robert E; Shimada, Takeshi; Crown, Lindsey M; Melnychenko, Olya; Yi, Janice; Matsumoto, Mitsuyuki; Tajinda, Katsunori; Mihara, Takuma; Adachi, Megumi; Siegel, Steven J.

Afiliação

Featherstone RE; Department of Psychiatry and Behavioral Sciences, University of Southern California, Los, Angeles, CA, USA.
Shimada T; Drug Discovery Research, Astellas Pharma, Inc, Tsukuba, Japan.
Crown LM; Department of Psychiatry and Behavioral Sciences, University of Southern California, Los, Angeles, CA, USA.
Melnychenko O; Department of Psychiatry and Behavioral Sciences, University of Southern California, Los, Angeles, CA, USA.
Yi J; Department of Psychiatry and Behavioral Sciences, University of Southern California, Los, Angeles, CA, USA.
Matsumoto M; Astellas Research Institute of America, San Diego, CA, USA.
Tajinda K; Astellas Research Institute of America, San Diego, CA, USA.
Mihara T; Drug Discovery Research, Astellas Pharma, Inc, Tsukuba, Japan.
Adachi M; Astellas Research Institute of America, San Diego, CA, USA. Electronic address: megumi.adachi@astellas.com.
Siegel SJ; Department of Psychiatry and Behavioral Sciences, University of Southern California, Los, Angeles, CA, USA. Electronic address: Steven.Siegel@med.usc.edu.

Neuroscience ; 499: 104-117, 2022 09 01.

Article em En | MEDLINE | ID: mdl-35901933

Assuntos

Proteína Quinase Tipo 2 Dependente de Cálcio-Calmodulina; Esquizofrenia; Animais; Cálcio; Proteína Quinase Tipo 2 Dependente de Cálcio-Calmodulina/genética; Proteína Quinase Tipo 2 Dependente de Cálcio-Calmodulina/metabolismo; Modelos Animais de Doenças; Eletroencefalografia; Humanos; Camundongos; Camundongos Knockout; Esquizofrenia/metabolismo

Palavras-chave

CaMKIIα; Cognitive impairment; Dentate Gyrus; Developmental Delay; EEG; Schizophrenia

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esquizofrenia / Proteína Quinase Tipo 2 Dependente de Cálcio-Calmodulina Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Neuroscience Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos

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