Combined exposure to PM<sub>2.5</sub> and high-fat diet facilitates the hepatic lipid metabolism disorders via ROS/miR-155/PPARÎ³ pathway.

Du, Zhou; Lin, Lisen; Li, Yang; Sun, Mengqi; Liang, Qingqing; Sun, Zhiwei; Duan, Junchao

Combined exposure to PM_2.5 and high-fat diet facilitates the hepatic lipid metabolism disorders via ROS/miR-155/PPARÎ³ pathway.

Du, Zhou; Lin, Lisen; Li, Yang; Sun, Mengqi; Liang, Qingqing; Sun, Zhiwei; Duan, Junchao.

Afiliação

Du Z; Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing, China; Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, China.
Lin L; Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing, China; Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, China.
Li Y; Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing, China; Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, China.
Sun M; Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing, China; Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, China.
Liang Q; Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing, China; Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, China.
Sun Z; Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing, China; Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, China. Electronic address: zwsun@ccmu.edu.cn.
Duan J; Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing, China; Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, China. Electronic address: jcduan@ccmu.edu.cn.

Free Radic Biol Med ; 190: 16-27, 2022 09.

Article em En | MEDLINE | ID: mdl-35940515

Assuntos

Transtornos do Metabolismo dos Lipídeos; MicroRNAs; Animais; Dieta Hiperlipídica; Metabolismo dos Lipídeos/genética; Transtornos do Metabolismo dos Lipídeos/metabolismo; Transtornos do Metabolismo dos Lipídeos/patologia; Lipídeos; Fígado/metabolismo; Camundongos; Camundongos Endogâmicos C57BL; MicroRNAs/genética; MicroRNAs/metabolismo; PPAR gama/metabolismo; Material Particulado/metabolismo; Material Particulado/toxicidade; Espécies Reativas de Oxigênio/metabolismo

Palavras-chave

C57BL/6J mice; Fine particulate matter; High-fat diet; MAFLD; ROS; miR-155

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: MicroRNAs / Transtornos do Metabolismo dos Lipídeos Limite: Animals Idioma: En Revista: Free Radic Biol Med Assunto da revista: BIOQUIMICA / MEDICINA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China

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