The Utility of Transcranial Stimulated Motor-Evoked Potential Alerts in Cervical Spine Surgery Varies Based on Preoperative Motor Status.
Spine (Phila Pa 1976)
; 47(23): 1659-1668, 2022 Dec 01.
Article
em En
| MEDLINE
| ID: mdl-35943242
ABSTRACT
STUDY DESIGN:
A prospective multicenter observational study.OBJECTIVE:
The aim was to investigate the validity of transcranial motor-evoked potentials (Tc-MEP) in cervical spine surgery and identify factors associated with positive predictive value when Tc-MEP alerts are occurred. SUMMARY OF BACKGROUND DATA The sensitivity and specificity of Tc-MEP for detecting motor paralysis are high; however, false-positives sometimes occur. MATERIALS ANDMETHODS:
The authors examined Tc-MEP in 2476 cases of cervical spine surgeries and compared patient backgrounds, type of spinal disorders, preoperative motor status, surgical factors, and the types of Tc-MEP alerts. Tc-MEP alerts were defined as an amplitude reduction of more than 70% from the control waveform. Tc-MEP results were classified into two groups false-positive and true-positive, and items that showed significant differences were extracted by univariate analysis and detected by multivariate analysis.RESULTS:
Overall sensitivity was 66% (segmental paralysis 33% and lower limb paralysis 95.8%) and specificity was 91.5%. Tc-MEP outcomes were 33 true-positives and 233 false-positives. Positive predictive value of general spine surgery was significantly higher in cases with a severe motor status than in a nonsevere motor status (19.5% vs . 6.7%, P =0.02), but not different in high-risk spine surgery (20.8% vs . 19.4%). However, rescue rates did not significantly differ regardless of motor status (48% vs . 50%). In a multivariate logistic analysis, a preoperative severe motor status [ P =0.041, odds ratio (OR) 2.46, 95% confidence interval (95% CI) 1.03-5.86] and Tc-MEP alerts during intradural tumor resection ( P <0.001, OR 7.44, 95% CI 2.64-20.96) associated with true-positives, while Tc-MEP alerts that could not be identified with surgical maneuvers ( P =0.011, OR 0.23, 95% CI 0.073-0.71) were associated with false-positives.CONCLUSION:
The utility of Tc-MEP in patients with a preoperative severe motor status was enhanced, even in those without high-risk spine surgery. Regardless of the motor status, appropriate interventions following Tc-MEP alerts may prevent postoperative paralysis.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças da Coluna Vertebral
/
Monitorização Neurofisiológica Intraoperatória
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Spine (Phila Pa 1976)
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Japão