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Crystal structures of Schistosoma mansoni histone deacetylase 8 reveal a novel binding site for allosteric inhibitors.
Saccoccia, Fulvio; Pozzetti, Luca; Gimmelli, Roberto; Butini, Stefania; Guidi, Alessandra; Papoff, Giuliana; Giannaccari, Marialaura; Brogi, Simone; Scognamiglio, Viviana; Gemma, Sandra; Ruberti, Giovina; Campiani, Giuseppe.
Afiliação
  • Saccoccia F; Institute of Biochemistry and Cell Biology, Italian National Research Council (IBBC-CNR), Adriano Buzzati-Traverso Campus, Monterotondo Scalo, Rome, Italy. Electronic address: fulvio.saccoccia@cnr.it.
  • Pozzetti L; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, Siena, Italy.
  • Gimmelli R; Institute of Biochemistry and Cell Biology, Italian National Research Council (IBBC-CNR), Adriano Buzzati-Traverso Campus, Monterotondo Scalo, Rome, Italy.
  • Butini S; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, Siena, Italy.
  • Guidi A; Institute of Biochemistry and Cell Biology, Italian National Research Council (IBBC-CNR), Adriano Buzzati-Traverso Campus, Monterotondo Scalo, Rome, Italy.
  • Papoff G; Institute of Biochemistry and Cell Biology, Italian National Research Council (IBBC-CNR), Adriano Buzzati-Traverso Campus, Monterotondo Scalo, Rome, Italy.
  • Giannaccari M; Institute of Biochemistry and Cell Biology, Italian National Research Council (IBBC-CNR), Adriano Buzzati-Traverso Campus, Monterotondo Scalo, Rome, Italy.
  • Brogi S; Department of Pharmacy, University of Pisa, Pisa, Italy.
  • Scognamiglio V; Institute of Crystallography, Italian National Research Council, Department of Chemical Sciences and Materials Technologies, Monterotondo, Italy.
  • Gemma S; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, Siena, Italy.
  • Ruberti G; Institute of Biochemistry and Cell Biology, Italian National Research Council (IBBC-CNR), Adriano Buzzati-Traverso Campus, Monterotondo Scalo, Rome, Italy. Electronic address: giovina.ruberti@cnr.it.
  • Campiani G; Department of Biotechnology, Chemistry and Pharmacy, DoE Department of Excellence 2018-2022, University of Siena, Siena, Italy. Electronic address: campiani@unisi.it.
J Biol Chem ; 298(10): 102375, 2022 10.
Article em En | MEDLINE | ID: mdl-35970392
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Contexto em Saúde: 3_ND Problema de saúde: 3_helminthiasis / 3_neglected_diseases / 3_schistosomiasis / 3_zoonosis Assunto principal: Schistosoma mansoni / Proteínas de Helminto / Inibidores de Histona Desacetilases / Histona Desacetilases / Anti-Helmínticos Limite: Animals / Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2022 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Contexto em Saúde: 3_ND Problema de saúde: 3_helminthiasis / 3_neglected_diseases / 3_schistosomiasis / 3_zoonosis Assunto principal: Schistosoma mansoni / Proteínas de Helminto / Inibidores de Histona Desacetilases / Histona Desacetilases / Anti-Helmínticos Limite: Animals / Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2022 Tipo de documento: Article