Lack of association of the KIR and HLA class I ligands with ZIKV infection in south and southeast of Brazil.
Mem Inst Oswaldo Cruz
; 117: e210194, 2022.
Article
em En
| MEDLINE
| ID: mdl-35976280
ABSTRACT
BACKGROUND:
Zika virus (ZIKV) is an emerging arbovirus associated with foetal malformations and neurological complications. The infection is usually associated with mild symptoms. The comparison between the allelic frequency of polymorphic genes in symptomatic infected individuals in the population can clarify the pathogenic mechanisms of ZIKV. During ZIKV infection, cytokines are produced and natural killer (NK) cells are recruited, whose activation depends on signaling pathways activated by specific receptors, such as killer cell immunoglobulin-like receptors (KIR). These molecules interact with human leukocyte antigen (HLA) class I ligands and are encoded by polymorphic genes.OBJECTIVES:
This study aimed to evaluate the frequency of allelic variants of the genes encoding the KIR receptors and their HLA class I ligands in 139 symptomatic ZIKV-patients and 170 controls negative for the virus, and to evaluate the role of these variants for ZIKV susceptibility.METHODS:
KIR and HLA class I genes were genotyped using the polymerase chain reaction-sequence specific oligonucleotide (PCR-SSO) technique.FINDINGS:
No significant differences in the frequency distribution of KIRs and KIR-HLA in patients compared to controls were observed. MAINCONCLUSIONS:
KIR and its HLA ligands might play a minor role in ZIKV infection in the south and southeast Brazilian individuals.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Contexto em Saúde:
2_ODS3
Problema de saúde:
2_enfermedades_transmissibles
Assunto principal:
Zika virus
/
Infecção por Zika virus
Tipo de estudo:
Risk_factors_studies
Limite:
Humans
País/Região como assunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Mem Inst Oswaldo Cruz
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Brasil