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Convenient Auditory-Based Language and Executive Function Test for Patients With Amyotrophic Lateral Sclerosis: A Pilot Study.
Ohdake, Reiko; Watanabe, Hirohisa; Kawabata, Kazuya; Ogura, Aya; Sato, Maki; Tanaka, Yasuhiro; Imai, Kazunori; Masuda, Michihito; Kato, Toshiyasu; Yokoi, Takamasa; Hara, Kazuhiro; Nakamura, Ryoichi; Atsuta, Naoki; Nakagawa, Masafumi; Katsuno, Masahisa; Sobue, Gen.
Afiliação
  • Ohdake R; Brain and Mind Research Center, Nagoya University, Nagoya, Japan.
  • Watanabe H; Department of Neurology, Fujita Health University School of Medicine, Toyoake, Japan.
  • Kawabata K; Brain and Mind Research Center, Nagoya University, Nagoya, Japan.
  • Ogura A; Department of Neurology, Fujita Health University School of Medicine, Toyoake, Japan.
  • Sato M; Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Tanaka Y; Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Imai K; Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Masuda M; Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Kato T; Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Yokoi T; Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Hara K; Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Nakamura R; Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Atsuta N; Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Nakagawa M; Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Katsuno M; Aichi Medical University, Nagakute, Japan.
  • Sobue G; International University of Health and Welfare, Narita, Japan.
Arch Clin Neuropsychol ; 38(1): 57-71, 2023 Jan 21.
Article em En | MEDLINE | ID: mdl-36003060
ABSTRACT

OBJECTIVE:

About 30%-50% of patients with amyotrophic lateral sclerosis (ALS) show cognitive impairment ranging from mild dysexecutive syndrome to frontotemporal dementia. We aimed to develop a brief cognitive test, convenient auditory-based language and executive function test (CABLET), for rapid detection of cognitive impairment in ALS, with reduced load on motor function.

METHOD:

The CABLET comprises two tests using auditory verbal stimuli Test 1, assessing word repetition and lexical judgment, and Test 2, evaluating verbal short-term memory and semantics knowledge. The administration time of Test 1 and Test 2 was 1 and 3-5 min, respectively. Overall, 61 patients with ALS and 46 age-, sex-, and education-matched healthy controls participated in this study. All participants underwent existing neuropsychological tests and the CABLET. We investigated the applicability of the CABLET to detect ALS with cognitive impairment (ALSci) from normal cognition.

RESULTS:

Receiver operating characteristic analyses showed that both the CABLET total and Test 2 had good diagnostic accuracy (area under the curve [AUC] total = 0.894, Test 2 = 0.893). Test 2 had the highest sensitivity (100% sensitivity and 71.4% specificity). No significant difference existed in the AUC between the analyses with and without age, education, and disease severity as covariates. Correlations were observed between the CABLET and established neuropsychological tests, supporting its good convergent validity.

CONCLUSIONS:

Our findings indicated that the CABLET could be useful in identifying ALSci quickly without adjusting for confounding factors. Further validation is required to evaluate it in larger groups and compare with ALS-specific cognitive screen.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Função Executiva / Esclerose Lateral Amiotrófica Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Arch Clin Neuropsychol Assunto da revista: NEUROLOGIA / PSICOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Japão

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Função Executiva / Esclerose Lateral Amiotrófica Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Arch Clin Neuropsychol Assunto da revista: NEUROLOGIA / PSICOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Japão
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