Your browser doesn't support javascript.
loading
The role of hypoxia-inducible factor-1 alpha in multidrug-resistant breast cancer.
Yong, Liyun; Tang, Shasha; Yu, Haixin; Zhang, Hongyi; Zhang, Yi; Wan, Yuan; Cai, Fengfeng.
Afiliação
  • Yong L; Department of Breast Surgery, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, China.
  • Tang S; Department of Breast Surgery, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, China.
  • Yu H; Department of Orthopedic Surgery, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, China.
  • Zhang H; Department of Breast Surgery, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, China.
  • Zhang Y; Department of Breast Surgery, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, China.
  • Wan Y; The Pq Laboratory of BiomeDx/Rx, Department of Biomedical Engineering, Binghamton University-SUNY, Binghamton, NY, United States.
  • Cai F; Department of Breast Surgery, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, China.
Front Oncol ; 12: 964934, 2022.
Article em En | MEDLINE | ID: mdl-36003773
ABSTRACT
Breast cancer is the most common cancer in women worldwide with increasing incidence. Significant therapeutics advances in the field of breast cancer have resulted in a growing number of treatment options, whereas de novo or acquired resistance is still a persistent clinical challenge. Drug resistance involves a variety of mechanisms, and hypoxia is one of the many causes. Hypoxia-inducible Factor-1 Alpha (HIF-1α) is a key transcription factor which can regulate the response of cells to hypoxia. HIF-1α can trigger anaerobic glycolysis of tumor cells, induce angiogenesis, promote the proliferation, invasion, and migration of tumor cells, and lead to multidrug resistance. This review mainly discusses the role of HIF-1α in the drug-resistant breast cancer and highlighted the potential of HIF-1α -targeted therapy.
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Front Oncol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Front Oncol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China
...