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CYP4F2-Catalyzed Metabolism of Arachidonic Acid Promotes Stromal Cell-Mediated Immunosuppression in Non-Small Cell Lung Cancer.
Chen, Xuehan; Liu, Yanzhuo; Wang, Yang; Wang, Chenlong; Chen, Xuewei; Xiong, Yu; Liu, Lilong; Yuan, Xi; Tang, Honglin; Shu, Chong; Zhang, Jing; Guo, Austin M; Chen, Honglei; Yang, Jing.
Afiliação
  • Chen X; Department of Pharmacology and Hubei Province Key Laboratory of Allergy and Immune-related Diseases, School of Basic Medical Sciences, Wuhan University, Wuhan, China.
  • Liu Y; Department of Pharmacology and Hubei Province Key Laboratory of Allergy and Immune-related Diseases, School of Basic Medical Sciences, Wuhan University, Wuhan, China.
  • Wang Y; Department of Pharmacology and Hubei Province Key Laboratory of Allergy and Immune-related Diseases, School of Basic Medical Sciences, Wuhan University, Wuhan, China.
  • Wang C; Department of Pharmacy, Zhongnan Hospital of Wuhan University, Wuhan, China.
  • Chen X; Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
  • Xiong Y; Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China.
  • Liu L; Department of Pharmacology and Hubei Province Key Laboratory of Allergy and Immune-related Diseases, School of Basic Medical Sciences, Wuhan University, Wuhan, China.
  • Yuan X; Department of Pharmacology and Hubei Province Key Laboratory of Allergy and Immune-related Diseases, School of Basic Medical Sciences, Wuhan University, Wuhan, China.
  • Tang H; Department of Pharmacology and Hubei Province Key Laboratory of Allergy and Immune-related Diseases, School of Basic Medical Sciences, Wuhan University, Wuhan, China.
  • Shu C; Department of Pharmacology and Hubei Province Key Laboratory of Allergy and Immune-related Diseases, School of Basic Medical Sciences, Wuhan University, Wuhan, China.
  • Zhang J; Animal Experimental Center of Wuhan University, Wuhan, China.
  • Guo AM; Department of Pharmacology, New York Medical College, Valhalla, New York.
  • Chen H; Department of Pathology, School of Basic Medical Sciences, Wuhan University, Wuhan, China.
  • Yang J; Department of Pharmacology and Hubei Province Key Laboratory of Allergy and Immune-related Diseases, School of Basic Medical Sciences, Wuhan University, Wuhan, China.
Cancer Res ; 82(21): 4016-4030, 2022 11 02.
Article em En | MEDLINE | ID: mdl-36006988
ABSTRACT

SIGNIFICANCE:

The identification of a role for CYP4F2-dependent metabolism in driving immune evasion in non-small cell lung cancer reveals a strategy to improve the efficacy of immunotherapy by inhibiting CYP4F2. See related article by Van Ginderachter, p. 3882.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma Pulmonar de Células não Pequenas / Família 4 do Citocromo P450 / Neoplasias Pulmonares Limite: Humans Idioma: En Revista: Cancer Res Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma Pulmonar de Células não Pequenas / Família 4 do Citocromo P450 / Neoplasias Pulmonares Limite: Humans Idioma: En Revista: Cancer Res Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China