A novel virotherapy encoding human interleukin-7 improves <i>ex vivo</i> T lymphocyte functions in immunosuppressed patients with septic shock and critically ill COVID-19.

Crausaz, Morgane; Monneret, Guillaume; Conti, Filippo; Lukaszewicz, Anne-Claire; Marchand, Jean-Baptiste; Martin, Perrine; Inchauspé, Geneviève; Venet, Fabienne

A novel virotherapy encoding human interleukin-7 improves ex vivo T lymphocyte functions in immunosuppressed patients with septic shock and critically ill COVID-19.

Crausaz, Morgane; Monneret, Guillaume; Conti, Filippo; Lukaszewicz, Anne-Claire; Marchand, Jean-Baptiste; Martin, Perrine; Inchauspé, Geneviève; Venet, Fabienne.

Afiliação

Crausaz M; Department of Infectious Diseases, Transgene SA, Lyon, France.
Monneret G; EA 7426 Pathophysiology of injury-induced immunosuppression (PI3), Lyon 1 University/Hospices Civils de Lyon/bioMérieux, Hôpital Edouard Herriot, Lyon, France.
Conti F; EA 7426 Pathophysiology of injury-induced immunosuppression (PI3), Lyon 1 University/Hospices Civils de Lyon/bioMérieux, Hôpital Edouard Herriot, Lyon, France.
Lukaszewicz AC; Hospices Civils de Lyon, Hôpital Edouard Herriot, Laboratoire d'Immunologie, Lyon, France.
Marchand JB; EA 7426 Pathophysiology of injury-induced immunosuppression (PI3), Lyon 1 University/Hospices Civils de Lyon/bioMérieux, Hôpital Edouard Herriot, Lyon, France.
Martin P; EA 7426 Pathophysiology of injury-induced immunosuppression (PI3), Lyon 1 University/Hospices Civils de Lyon/bioMérieux, Hôpital Edouard Herriot, Lyon, France.
Inchauspé G; Hospices Civils de Lyon, Hôpital Edouard Herriot, Service d'anesthésie-réanimation, Lyon, France.
Venet F; Department of Vectorology, Transgene SA, Illkirch-Graffenstraden, France.

Front Immunol ; 13: 939899, 2022.

Article em En | MEDLINE | ID: mdl-36045686

Assuntos

COVID-19; Sepse; Choque Séptico; Animais; COVID-19/terapia; Estado Terminal; Citocinas/metabolismo; Humanos; Interleucina-7/metabolismo; Camundongos; Receptores de Antígenos de Linfócitos T/metabolismo; Fator de Transcrição STAT5/metabolismo; Sepse/terapia

Palavras-chave

COVID-19; T lymphocytes; immunostimulation; interleukin-7; modified virus Ankara; sepsis; virotherapy

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Choque Séptico / Sepse / COVID-19 Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Front Immunol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: França

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