Artificial pore blocker acts specifically on voltage-gated potassium channel isoform K<sub>V</sub>1.6.

Gigolaev, Andrei M; Lushpa, Vladislav A; Pinheiro-Junior, Ernesto L; Tabakmakher, Valentin M; Peigneur, Steve; Ignatova, Anastasija A; Feofanov, Alexey V; Efremov, Roman G; Mineev, Konstantin S; Tytgat, Jan; Vassilevski, Alexander A

Artificial pore blocker acts specifically on voltage-gated potassium channel isoform K_V1.6.

Gigolaev, Andrei M; Lushpa, Vladislav A; Pinheiro-Junior, Ernesto L; Tabakmakher, Valentin M; Peigneur, Steve; Ignatova, Anastasija A; Feofanov, Alexey V; Efremov, Roman G; Mineev, Konstantin S; Tytgat, Jan; Vassilevski, Alexander A.

Afiliação

Gigolaev AM; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
Lushpa VA; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia; Moscow Institute of Physics and Technology, State University, Moscow Region, Russia.
Pinheiro-Junior EL; Toxicology and Pharmacology, University of Leuven, Leuven, Belgium.
Tabakmakher VM; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia; Institute of Life Sciences and Biomedicine, Far Eastern Federal University, Vladivostok, Russia.
Peigneur S; Toxicology and Pharmacology, University of Leuven, Leuven, Belgium.
Ignatova AA; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
Feofanov AV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
Efremov RG; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
Mineev KS; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia; Moscow Institute of Physics and Technology, State University, Moscow Region, Russia.
Tytgat J; Toxicology and Pharmacology, University of Leuven, Leuven, Belgium.
Vassilevski AA; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia; Moscow Institute of Physics and Technology, State University, Moscow Region, Russia. Electronic address: avas@ibch.ru.

J Biol Chem ; 298(11): 102467, 2022 11.

Article em En | MEDLINE | ID: mdl-36087839

Assuntos

Canais de Potássio de Abertura Dependente da Tensão da Membrana; Canais de Potássio de Abertura Dependente da Tensão da Membrana/genética; Canais de Potássio de Abertura Dependente da Tensão da Membrana/metabolismo; Sequência de Aminoácidos; Bloqueadores dos Canais de Potássio/química; Peptídeos/química; Ligantes; Isoformas de Proteínas/genética; Isoformas de Proteínas/metabolismo; Canal de Potássio Kv1.3/genética; Canal de Potássio Kv1.3/metabolismo; Canal de Potássio Kv1.1/metabolismo; Canal de Potássio Kv1.2/metabolismo; Canal de Potássio Kv1.5/metabolismo

Palavras-chave

NMR; molecular dynamics; molecular modeling; protein design; protein structure; voltage-gated potassium channel; α-hairpinin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Canais de Potássio de Abertura Dependente da Tensão da Membrana Idioma: En Revista: J Biol Chem Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Federação Russa

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