A novel cysteine protease inhibitor in Baylisascaris schroederi migratory larvae regulates inflammasome activation through the TLR4-ROS-NLRP3 pathway.

Xu, Jingyun; Gu, Xiaobin; Xie, Yue; He, Ran; Xu, Jing; Xiong, Lang; Peng, Xuerong; Yang, Guangyou

Xu, Jingyun; Gu, Xiaobin; Xie, Yue; He, Ran; Xu, Jing; Xiong, Lang; Peng, Xuerong; Yang, Guangyou.

Afiliação

Xu J; Department of Parasitology, College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, 611130, China.
Gu X; Department of Parasitology, College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, 611130, China.
Xie Y; Department of Parasitology, College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, 611130, China.
He R; Department of Parasitology, College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, 611130, China.
Xu J; Department of Parasitology, College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, 611130, China.
Xiong L; Department of Parasitology, College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, 611130, China.
Peng X; Department of Chemistry, College of Life and Basic Science, Sichuan Agricultural University, Wenjiang, 611130, China.
Yang G; Department of Parasitology, College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, 611130, China. guangyou1963@126.com.

Parasit Vectors ; 15(1): 334, 2022 Sep 23.

Article em En | MEDLINE | ID: mdl-36151570

Assuntos

Ascaridoidea; Ursidae; Animais; Ascaridoidea/metabolismo; Caspase 1/metabolismo; Inibidores de Cisteína Proteinase; Inflamassomos; Interleucina-18; Larva/metabolismo; Camundongos; Proteína 3 que Contém Domínio de Pirina da Família NLR/genética; Proteína 3 que Contém Domínio de Pirina da Família NLR/metabolismo; Proteínas NLR; Espécies Reativas de Oxigênio/metabolismo; Sincalida; Receptor 4 Toll-Like/genética

Palavras-chave

Baylisascaris schroederi; Cysteine protease inhibitors; Inflammasome; Pyroptosis; ROS

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ursidae / Ascaridoidea Limite: Animals Idioma: En Revista: Parasit Vectors Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China

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