Robust genome editing via modRNA-based Cas9 or base editor in human pluripotent stem cells.

Haideri, Tahir; Howells, Alessandro; Jiang, Yuqian; Yang, Jian; Bao, Xiaoping; Lian, Xiaojun Lance

Haideri, Tahir; Howells, Alessandro; Jiang, Yuqian; Yang, Jian; Bao, Xiaoping; Lian, Xiaojun Lance.

Afiliação

Haideri T; Department of Biomedical Engineering, Pennsylvania State University, University Park, PA 16802, USA.
Howells A; Department of Biomedical Engineering, Pennsylvania State University, University Park, PA 16802, USA.
Jiang Y; Department of Biomedical Engineering, Pennsylvania State University, University Park, PA 16802, USA.
Yang J; Department of Biomedical Engineering, Pennsylvania State University, University Park, PA 16802, USA.
Bao X; The Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA 16802, USA.
Lian XL; Davidson School of Chemical Engineering, Purdue University, West Lafayette, IN 47907, USA.

Cell Rep Methods ; 2(9): 100290, 2022 09 19.

Article em En | MEDLINE | ID: mdl-36160051

Assuntos

Edição de Genes; Células-Tronco Pluripotentes; Humanos; Edição de Genes/métodos; Sistemas CRISPR-Cas/genética; RNA Mensageiro/genética; Plasmídeos

Palavras-chave

ABE8e; CRISPR-Cas9; adenine base editors; base editors; chemically modified mRNA; gene editing; genome editing; human pluripotent stem cells; iPSCs; modRNA

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células-Tronco Pluripotentes / Edição de Genes Limite: Humans Idioma: En Revista: Cell Rep Methods Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos

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