Cationic amino acid transporter-1 (CAT-1) promotes fibroblast-like synoviocyte proliferation and cytokine secretion by taking up L-arginine in rheumatoid arthritis.

Lu, Ying; Hao, Chongbo; Yu, Shanshan; Ma, Zuan; Fu, Xuelian; Qin, Mingqing; Ding, Menglei; Xu, Zengguang; Fan, Lieying

Lu, Ying; Hao, Chongbo; Yu, Shanshan; Ma, Zuan; Fu, Xuelian; Qin, Mingqing; Ding, Menglei; Xu, Zengguang; Fan, Lieying.

Afiliação

Lu Y; Clinical Laboratory Department, Shanghai East Hospital, School of Medicine, Tongji University, 150 Jimo Road, Pudong, Shanghai, 200120, China. luying_1010@163.com.
Hao C; Shanghai East Hospital Ji'an Hospital, 80 Ji'an South Road, Ji'an City, 343000, Jiangxi Province, China. luying_1010@163.com.
Yu S; Research Center for Translational Medicine, Shanghai East Hospital, School of Medicine, Tongji University, 150 Jimo Road, Pudong, Shanghai, 200120, China.
Ma Z; Clinical Laboratory Department, Shanghai East Hospital, School of Medicine, Tongji University, 150 Jimo Road, Pudong, Shanghai, 200120, China.
Fu X; Research Center for Translational Medicine, Shanghai East Hospital, School of Medicine, Tongji University, 150 Jimo Road, Pudong, Shanghai, 200120, China.
Qin M; Research Center for Translational Medicine, Shanghai East Hospital, School of Medicine, Tongji University, 150 Jimo Road, Pudong, Shanghai, 200120, China.
Ding M; Research Center for Translational Medicine, Shanghai East Hospital, School of Medicine, Tongji University, 150 Jimo Road, Pudong, Shanghai, 200120, China.
Xu Z; Clinical Laboratory Department, Shanghai East Hospital, School of Medicine, Tongji University, 150 Jimo Road, Pudong, Shanghai, 200120, China.
Fan L; Research Center for Translational Medicine, Shanghai East Hospital, School of Medicine, Tongji University, 150 Jimo Road, Pudong, Shanghai, 200120, China. xuzg1998@163.com.

Arthritis Res Ther ; 24(1): 234, 2022 10 17.

Article em En | MEDLINE | ID: mdl-36253807

Assuntos

Arginina; Artrite Experimental; Artrite Reumatoide; Transportador 1 de Aminoácidos Catiônicos; Sinoviócitos; Animais; Camundongos; Aminoácidos/metabolismo; Artrite Experimental/metabolismo; Artrite Reumatoide/tratamento farmacológico; Transportador 1 de Aminoácidos Catiônicos/metabolismo; Movimento Celular; Proliferação de Células; Células Cultivadas; Cromatografia Líquida; Citocinas/metabolismo; Fibroblastos/metabolismo; Interleucina-6/metabolismo; Interleucina-8/metabolismo; Camundongos Endogâmicos CBA; RNA Mensageiro/metabolismo; RNA Interferente Pequeno/metabolismo; RNA Interferente Pequeno/farmacologia; RNA Interferente Pequeno/uso terapêutico; Membrana Sinovial/metabolismo; Sinoviócitos/metabolismo; Espectrometria de Massas em Tandem

Palavras-chave

Cationic amino acid transporter-1; Fibroblast-like synoviocytes; Hyperplasia; L-rginine; Rheumatoid arthritis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Arginina / Artrite Experimental / Artrite Reumatoide / Transportador 1 de Aminoácidos Catiônicos / Sinoviócitos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Arthritis Res Ther Assunto da revista: REUMATOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China

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