TRIM59 guards ER proteostasis and prevents Bortezomib-mediated colorectal cancer (CRC) cells' killing.

Feng, Xuejia; Yang, Gui; Zhang, Litian; Tao, Shishi; Shim, Joong Sup; Chen, Liang; Wu, Qingxia

Feng, Xuejia; Yang, Gui; Zhang, Litian; Tao, Shishi; Shim, Joong Sup; Chen, Liang; Wu, Qingxia.

Afiliação

Feng X; Key laboratory of clinical veterinary medicine in Tibet, Tibet Agriculture and Animal Husbandry College, 860000, Linzhi, Tibet, People's Republic of China.
Yang G; Shenzhen Laboratory of Tumor Cell Biology, Center for Protein and Cell-based Drugs, Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, 518055, Shenzhen, P. R. China.
Zhang L; Department of Otolaryngology, Longgang Central Hospital, 518055, Shenzhen, P. R. China.
Tao S; Shenzhen Laboratory of Tumor Cell Biology, Center for Protein and Cell-based Drugs, Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, 518055, Shenzhen, P. R. China.
Shim JS; Shenzhen Laboratory of Tumor Cell Biology, Center for Protein and Cell-based Drugs, Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, 518055, Shenzhen, P. R. China.
Chen L; Cancer Centre, Faculty of Health Sciences, University of Macau, Avenida da Universidade, Taipa, Macau, SAR, China.
Wu Q; Cancer Centre, Faculty of Health Sciences, University of Macau, Avenida da Universidade, Taipa, Macau, SAR, China.

Invest New Drugs ; 40(6): 1244-1253, 2022 12.

Article em En | MEDLINE | ID: mdl-36306030

Assuntos

Neoplasias Colorretais; Proteostase; Humanos; Bortezomib/farmacologia; Retículo Endoplasmático/metabolismo; Resposta a Proteínas não Dobradas; Estresse do Retículo Endoplasmático; Apoptose; Neoplasias Colorretais/tratamento farmacológico; Neoplasias Colorretais/metabolismo; Proteínas com Motivo Tripartido/metabolismo; Peptídeos e Proteínas de Sinalização Intracelular/metabolismo; Peptídeos e Proteínas de Sinalização Intracelular/farmacologia

Palavras-chave

Bortezomib; Colorectal cancer; ER-associated degradation; ER-stress; TRIM59; Unfolded protein response

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Contexto em Saúde: 6_ODS3_enfermedades_notrasmisibles Problema de saúde: 6_colon_rectum_cancers Assunto principal: Neoplasias Colorretais / Proteostase Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Invest New Drugs Ano de publicação: 2022 Tipo de documento: Article

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