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Deep phenotyping and lifetime trajectories reveal limited effects of longevity regulators on the aging process in C57BL/6J mice.
Xie, Kan; Fuchs, Helmut; Scifo, Enzo; Liu, Dan; Aziz, Ahmad; Aguilar-Pimentel, Juan Antonio; Amarie, Oana Veronica; Becker, Lore; da Silva-Buttkus, Patricia; Calzada-Wack, Julia; Cho, Yi-Li; Deng, Yushuang; Edwards, A Cole; Garrett, Lillian; Georgopoulou, Christina; Gerlini, Raffaele; Hölter, Sabine M; Klein-Rodewald, Tanja; Kramer, Michael; Leuchtenberger, Stefanie; Lountzi, Dimitra; Mayer-Kuckuk, Phillip; Nover, Lena L; Oestereicher, Manuela A; Overkott, Clemens; Pearson, Brandon L; Rathkolb, Birgit; Rozman, Jan; Russ, Jenny; Schaaf, Kristina; Spielmann, Nadine; Sanz-Moreno, Adrián; Stoeger, Claudia; Treise, Irina; Bano, Daniele; Busch, Dirk H; Graw, Jochen; Klingenspor, Martin; Klopstock, Thomas; Mock, Beverly A; Salomoni, Paolo; Schmidt-Weber, Carsten; Weiergräber, Marco; Wolf, Eckhard; Wurst, Wolfgang; Gailus-Durner, Valérie; Breteler, Monique M B; Hrabe de Angelis, Martin; Ehninger, Dan.
Afiliação
  • Xie K; Translational Biogerontology Lab, German Center for Neurodegenerative Diseases (DZNE), Venusberg-Campus 1/99, 53127, Bonn, Germany.
  • Fuchs H; Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.
  • Scifo E; Translational Biogerontology Lab, German Center for Neurodegenerative Diseases (DZNE), Venusberg-Campus 1/99, 53127, Bonn, Germany.
  • Liu D; Population Health Sciences, German Center for Neurodegenerative Diseases (DZNE), Venusberg-Campus 1/99, 53127, Bonn, Germany.
  • Aziz A; Population Health Sciences, German Center for Neurodegenerative Diseases (DZNE), Venusberg-Campus 1/99, 53127, Bonn, Germany.
  • Aguilar-Pimentel JA; Department of Neurology, Faculty of Medicine, University of Bonn, Bonn, Germany.
  • Amarie OV; Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.
  • Becker L; Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.
  • da Silva-Buttkus P; Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.
  • Calzada-Wack J; Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.
  • Cho YL; Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.
  • Deng Y; Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.
  • Edwards AC; Translational Biogerontology Lab, German Center for Neurodegenerative Diseases (DZNE), Venusberg-Campus 1/99, 53127, Bonn, Germany.
  • Garrett L; Translational Biogerontology Lab, German Center for Neurodegenerative Diseases (DZNE), Venusberg-Campus 1/99, 53127, Bonn, Germany.
  • Georgopoulou C; Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.
  • Gerlini R; Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.
  • Hölter SM; Translational Biogerontology Lab, German Center for Neurodegenerative Diseases (DZNE), Venusberg-Campus 1/99, 53127, Bonn, Germany.
  • Klein-Rodewald T; Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.
  • Kramer M; Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.
  • Leuchtenberger S; Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.
  • Lountzi D; Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.
  • Mayer-Kuckuk P; GEMoaB GmbH, Tatzberg 47, 01307, Dresden, Germany.
  • Nover LL; Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.
  • Oestereicher MA; Translational Biogerontology Lab, German Center for Neurodegenerative Diseases (DZNE), Venusberg-Campus 1/99, 53127, Bonn, Germany.
  • Overkott C; Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.
  • Pearson BL; Translational Biogerontology Lab, German Center for Neurodegenerative Diseases (DZNE), Venusberg-Campus 1/99, 53127, Bonn, Germany.
  • Rathkolb B; Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.
  • Rozman J; Translational Biogerontology Lab, German Center for Neurodegenerative Diseases (DZNE), Venusberg-Campus 1/99, 53127, Bonn, Germany.
  • Russ J; Translational Biogerontology Lab, German Center for Neurodegenerative Diseases (DZNE), Venusberg-Campus 1/99, 53127, Bonn, Germany.
  • Schaaf K; Mailman School of Public Health, Columbia University, 630W. 168th St., New York, NY, 10032, USA.
  • Spielmann N; Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.
  • Sanz-Moreno A; Member of German Center for Diabetes Research (DZD), 85764, Neuherberg, Germany.
  • Stoeger C; Institute of Molecular Animal Breeding and Biotechnology, Gene Center, Ludwig-Maximilians-University Munich, Munich, Germany.
  • Treise I; Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.
  • Bano D; Member of German Center for Diabetes Research (DZD), 85764, Neuherberg, Germany.
  • Busch DH; Institute of Molecular Genetics of the Czech Academy of Sciences, Czech Centre for Phenogenomics, Prumyslova 595, Vestec, 252 50, Czech Republic.
  • Graw J; Nuclear Function Lab, German Center for Neurodegenerative Diseases (DZNE), Venusberg-Campus 1/99, 53127, Bonn, Germany.
  • Klingenspor M; Translational Biogerontology Lab, German Center for Neurodegenerative Diseases (DZNE), Venusberg-Campus 1/99, 53127, Bonn, Germany.
  • Klopstock T; Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.
  • Mock BA; Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.
  • Salomoni P; Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.
  • Schmidt-Weber C; Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.
  • Weiergräber M; Aging and Neurodegeneration Lab, German Center for Neurodegenerative Diseases (DZNE), Venusberg-Campus 1/99, 53127, Bonn, Germany.
  • Wolf E; Institute for Medical Microbiology, Immunology, and Hygiene, Technische Universität München, 81675, Munich, Germany.
  • Wurst W; Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764, Neuherberg, Germany.
  • Gailus-Durner V; Molecular Nutritional Medicine, Else Kröner-Fresenius Center, Technische Universität München, 85350, Freising-Weihenstephan, Germany.
  • Breteler MMB; Friedrich-Baur-Institut, Department of Neurology, Ludwig-Maximilians-University Munich, 80336, Munich, Germany.
  • Hrabe de Angelis M; DZNE, German Center for Neurodegenerative Diseases, 80336, Munich, Germany.
  • Ehninger D; Munich Cluster for Systems Neurology (SyNergy), 80336, Munich, Germany.
Nat Commun ; 13(1): 6830, 2022 11 11.
Article em En | MEDLINE | ID: mdl-36369285
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Envelhecimento / Longevidade Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Alemanha
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Envelhecimento / Longevidade Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Alemanha