Akkermansia muciniphila ameliorates chronic kidney disease interstitial fibrosis via the gut-renal axis.
Microb Pathog
; 174: 105891, 2023 Jan.
Article
em En
| MEDLINE
| ID: mdl-36427659
ABSTRACT
CONTEXT Chronic kidney disease (CKD) affects approximately 10% of the global population. The abundance of Akkermansia muciniphila (AKK) is significantly reduced in CKD patients. OBJECTIVE:
This study investigated the effects of AKK bacteria on kidney damage and the renal interstitium in rats with CKD. MATERIALS ANDMETHODS:
CKD model 5/6 nephrectomy rats were used. CKD rats were supplemented with AKK (2 × 108 cfu/0.2 mL) for 8 weeks.RESULTS:
AKK administration significantly suppressed epithelial-mesenchymal transition (EMT), and high-throughput 16S rRNA pyrosequencing showed that AKK supplementation restored the disordered intestinal microecology in CKD rats. AKK also enhanced the intestinal mucosal barrier function. AKK may regulate the intestinal microecology and reduce renal interstitial fibrosis by enhancing the abundance of probiotics and reducing damage to the intestinal mucosal barrier.CONCLUSION:
The results suggest that AKK administration could be a novel therapeutic strategy for treating renal fibrosis and CKD.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Insuficiência Renal Crônica
/
Rim
Limite:
Animals
Idioma:
En
Revista:
Microb Pathog
Assunto da revista:
DOENCAS TRANSMISSIVEIS
/
MICROBIOLOGIA
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
China