CRISPR/SaCas9 mutagenesis of stromal interaction molecule 1 in proopiomelanocortin neurons increases glutamatergic excitability and protects against diet-induced obesity.

Qiu, Jian; Bosch, Martha A; Stincic, Todd L; Hunker, Avery C; Zweifel, Larry S; Rønnekleiv, Oline K; Kelly, Martin J

Qiu, Jian; Bosch, Martha A; Stincic, Todd L; Hunker, Avery C; Zweifel, Larry S; Rønnekleiv, Oline K; Kelly, Martin J.

Afiliação

Qiu J; Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, OR 97239, USA. Electronic address: qiuj@ohsu.edu.
Bosch MA; Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, OR 97239, USA.
Stincic TL; Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, OR 97239, USA.
Hunker AC; Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195, USA.
Zweifel LS; Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195, USA; Department of Pharmacology, University of Washington, Seattle, WA 98195, USA.
Rønnekleiv OK; Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, OR 97239, USA; Division of Neuroscience, Oregon National Primate Research Center, Beaverton, OR 97006, USA.
Kelly MJ; Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, OR 97239, USA; Division of Neuroscience, Oregon National Primate Research Center, Beaverton, OR 97006, USA. Electronic address: kellym@ohsu.edu.

Mol Metab ; 66: 101645, 2022 12.

Article em En | MEDLINE | ID: mdl-36442744

Assuntos

Neurônios; Obesidade; Molécula 1 de Interação Estromal; Animais; Masculino; Camundongos; Cálcio/metabolismo; Dieta Hiperlipídica/efeitos adversos; Mutagênese; Neurônios/metabolismo; Obesidade/genética; Obesidade/metabolismo; Pró-Opiomelanocortina/genética; Pró-Opiomelanocortina/metabolismo; Molécula 1 de Interação Estromal/genética; Molécula 1 de Interação Estromal/metabolismo

Palavras-chave

CRISPR/SaCas9; Glutamate; High fat diet; POMC; STIM1; TRPC 5 channel

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Molécula 1 de Interação Estromal / Neurônios / Obesidade Limite: Animals Idioma: En Revista: Mol Metab Ano de publicação: 2022 Tipo de documento: Article

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