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Vaccination induces HIV broadly neutralizing antibody precursors in humans.
Leggat, David J; Cohen, Kristen W; Willis, Jordan R; Fulp, William J; deCamp, Allan C; Kalyuzhniy, Oleksandr; Cottrell, Christopher A; Menis, Sergey; Finak, Greg; Ballweber-Fleming, Lamar; Srikanth, Abhinaya; Plyler, Jason R; Schiffner, Torben; Liguori, Alessia; Rahaman, Farhad; Lombardo, Angela; Philiponis, Vincent; Whaley, Rachael E; Seese, Aaron; Brand, Joshua; Ruppel, Alexis M; Hoyland, Wesley; Yates, Nicole L; Williams, LaTonya D; Greene, Kelli; Gao, Hongmei; Mahoney, Celia R; Corcoran, Martin M; Cagigi, Alberto; Taylor, Alison; Brown, David M; Ambrozak, David R; Sincomb, Troy; Hu, Xiaozhen; Tingle, Ryan; Georgeson, Erik; Eskandarzadeh, Saman; Alavi, Nushin; Lu, Danny; Mullen, Tina-Marie; Kubitz, Michael; Groschel, Bettina; Maenza, Janine; Kolokythas, Orpheus; Khati, Nadia; Bethony, Jeffrey; Crotty, Shane; Roederer, Mario; Karlsson Hedestam, Gunilla B; Tomaras, Georgia D.
Afiliação
  • Leggat DJ; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
  • Cohen KW; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
  • Willis JR; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Fulp WJ; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • deCamp AC; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Kalyuzhniy O; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
  • Cottrell CA; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
  • Menis S; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Finak G; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Ballweber-Fleming L; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Srikanth A; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Plyler JR; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Schiffner T; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Liguori A; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Rahaman F; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Lombardo A; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Philiponis V; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
  • Whaley RE; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
  • Seese A; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
  • Brand J; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
  • Ruppel AM; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Hoyland W; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Yates NL; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Williams LD; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Greene K; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Gao H; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Mahoney CR; IAVI, New York, NY 10004, USA.
  • Corcoran MM; IAVI, New York, NY 10004, USA.
  • Cagigi A; IAVI, New York, NY 10004, USA.
  • Taylor A; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
  • Brown DM; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
  • Ambrozak DR; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
  • Sincomb T; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
  • Hu X; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
  • Tingle R; Center for Human Systems Immunology, Departments of Surgery, Immunology, Molecular Genetics and Microbiology, Duke University, Durham, NC 27701, USA.
  • Georgeson E; Center for Human Systems Immunology, Departments of Surgery, Immunology, Molecular Genetics and Microbiology, Duke University, Durham, NC 27701, USA.
  • Eskandarzadeh S; Duke University Medical Center, Durham, NC 27701, USA.
  • Alavi N; Duke University Medical Center, Durham, NC 27701, USA.
  • Lu D; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.
  • Mullen TM; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
  • Kubitz M; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
  • Groschel B; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
  • Maenza J; The Foundation for the National Institutes of Health, North Bethesda, MD 20852, USA.
  • Kolokythas O; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
  • Khati N; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Bethony J; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Crotty S; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Roederer M; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Karlsson Hedestam GB; Center for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Tomaras GD; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
Science ; 378(6623): eadd6502, 2022 12 02.
Article em En | MEDLINE | ID: mdl-36454825
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Contexto em Saúde: 1_ASSA2030 / 2_ODS3 Problema de saúde: 1_doencas_nao_transmissiveis / 2_enfermedades_transmissibles Assunto principal: Anticorpos Anti-HIV / Infecções por HIV / Vacinas contra a AIDS / Cadeias Pesadas de Imunoglobulinas / Cadeias Leves de Imunoglobulina / Anticorpos Amplamente Neutralizantes / Células Germinativas Tipo de estudo: Clinical_trials Limite: Adult / Female / Humans / Male Idioma: En Revista: Science Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Contexto em Saúde: 1_ASSA2030 / 2_ODS3 Problema de saúde: 1_doencas_nao_transmissiveis / 2_enfermedades_transmissibles Assunto principal: Anticorpos Anti-HIV / Infecções por HIV / Vacinas contra a AIDS / Cadeias Pesadas de Imunoglobulinas / Cadeias Leves de Imunoglobulina / Anticorpos Amplamente Neutralizantes / Células Germinativas Tipo de estudo: Clinical_trials Limite: Adult / Female / Humans / Male Idioma: En Revista: Science Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos